|Flow Cytometry (Flow)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Mouse monoclonal antibodies raised against human CD163.|
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage conditions||4° C, do not freeze|
MA5-17720 targets CD163/M130 in FACS applications and shows reactivity with Human samples.
The MA5-17720 immunogen is mouse monoclonal antibodies raised against human CD163.
CD163 is a 130kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant.
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Protein Aliases: CD163; CD163 antigen; Hemoglobin scavenger receptor; macrophage-associated antigen; Scavenger receptor cysteine-rich type 1 protein M130
Gene Aliases: CD163; M130; MM130; SCARI1
UniProt ID: (Human) Q86VB7
Entrez Gene ID: (Human) 9332
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