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Invitrogen
CD26 Monoclonal Antibody (BA5b), APC
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Product Details
CD2605
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
BA5b
Immunogen
Human CD26
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
PBS with BSA, sucrose
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.
Target Information
CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
Analyte Specific Reagent
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
Bioinformatics
Protein Aliases: ADABP; ADCP-2; Adenosine deaminase complexing protein 2; CD26; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP IV; DPP-IV; Gly-Pro naphthylamidase; Post-proline dipeptidyl aminopeptidase IV; T-cell activation antigen CD26; TP103; Xaa-Pro-dipeptidylaminopeptidase
Gene Aliases: ADABP; ADCP2; CD26; DPP4; DPPIV; TP103
UniProt ID: (Human) P27487
Entrez Gene ID: (Human) 1803
virus receptor activity
protease binding
aminopeptidase activity
serine-type endopeptidase activity
receptor binding
protein binding
peptidase activity
serine-type peptidase activity
dipeptidyl-peptidase activity
hydrolase activity
identical protein binding
protein homodimerization activity
chemorepellent activity
behavioral fear response
response to hypoxia
proteolysis
cell adhesion
positive regulation of cell proliferation
negative regulation of extracellular matrix disassembly
peptide hormone processing
receptor-mediated endocytosis of virus by host cell
T cell costimulation
regulation of cell-cell adhesion mediated by integrin
locomotory exploration behavior
psychomotor behavior
T cell activation
endothelial cell migration
viral entry into host cell
receptor-mediated virion attachment to host cell
negative chemotaxis
membrane fusion
negative regulation of neutrophil chemotaxis
glucagon processing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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