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Invitrogen
CD263 (TRAIL-R3) Monoclonal Antibody (TRAIL-R3-02)
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FIGURE: 1 / 2
CD263 (TRAIL-R3) Antibody (MA1-19729) in Flow
Separation of CD263 transfected HEK-293 cells (red-filled) from nontransfected HEK-293 cells (black-dashed) in flow cytometry analysis (surface staining) stained using anti-human CD263 (TRAIL-R3-02) purified Monoclonal antibody (Product # MA1-19729) (azide free, concentration in sample 16 µg/mL) GAM APC.
Product Details
MA1-19729
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TRAIL-R3-02
Immunogen
TRAIL-R3 (aa 1-280) - hIgGhc fusion protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Target Information
TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; cytotoxic TRAIL receptor-3; DcR1; Decoy receptor 1; Decoy TRAIL receptor without death domain; DR4 homolog; Lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF receptor family member; lacks a cytoplasmic domain; TNF-related apoptosis-inducing ligand receptor 3; TNFR family member; TNFRSF10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; unnamed protein product
Gene Aliases: CD263; DCR1; DCR1-TNFR; LIT; TNFRSF10C; TRAIL-R3; TRAILR3; TRID; UNQ321/PRO366
UniProt ID: (Human) O14798
Entrez Gene ID: (Human) 8794
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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