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Bioss
CD2AP Polyclonal Antibody
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Product Details
BS-0512R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CD2AP, amino acids 561-641.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; mesenchyme to epithelium transition protein, SH3 domains; Mesenchyme-to-epithelium transition protein with SH3 domains 1; METS-1; SH3 domain-containing adapter protein; SH3 domain-containing adaptor protein METS-1
Gene Aliases: AL024079; C78928; CD2AP; CMS; METS-1; Mets1
UniProt ID: (Human) Q9Y5K6, (Mouse) Q9JLQ0
Entrez Gene ID: (Human) 23607, (Mouse) 12488, (Rat) 316258
cell cycle
mitotic nuclear division
vesicle organization
single organismal cell-cell adhesion
cell migration
negative regulation of transforming growth factor beta1 production
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of receptor-mediated endocytosis
cell division
positive regulation of protein localization to nucleus
regulation of actin cytoskeleton reorganization
protein complex assembly
substrate-dependent cell migration, cell extension
cytoskeleton organization
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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