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Invitrogen
CD2AP Polyclonal Antibody
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Product Details
PA5-117848
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human CD2AP fragment
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology (SH) 3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein
Gene Aliases: CD2AP; CMS
UniProt ID: (Human) Q9Y5K6
Entrez Gene ID: (Human) 23607
immunological synapse formation
kidney development
liver development
endothelium development
lipid metabolic process
apoptotic process
substrate-dependent cell migration, cell extension
inflammatory response
response to oxidative stress
actin filament organization
signal transduction
cell proliferation
male gonad development
protein secretion
response to wounding
response to virus
gene expression
protein transport
cell migration
actin filament polymerization
cell differentiation
protein catabolic process
neuron projection development
Rab protein signal transduction
glomerulus development
response to insulin
transforming growth factor beta1 production
negative regulation of transforming growth factor beta1 production
regulation of actin cytoskeleton organization
maintenance of blood-brain barrier
neurotrophin signaling pathway
nerve growth factor signaling pathway
protein kinase B signaling
negative regulation of neuron apoptotic process
cell-cell adhesion mediated by cadherin
cell-cell junction organization
glucose import
filopodium assembly
neurotrophin TRK receptor signaling pathway
regulation of synaptic plasticity
lymph node development
collateral sprouting
positive regulation of protein secretion
synapse organization
T cell receptor signaling pathway
negative regulation of small GTPase mediated signal transduction
protein heterooligomerization
cell division
stress-activated MAPK cascade
localization of cell
adipose tissue development
membrane organization
protein-containing complex assembly
ERK1 and ERK2 cascade
response to transforming growth factor beta
glomerular visceral epithelial cell differentiation
renal albumin absorption
positive regulation of protein localization to nucleus
response to glial cell derived neurotrophic factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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