This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: VDFDSLTVRT SKETDVVNFD DIASSENLLH LTANRPKMPG RRLPGRFNGG HSPTHSPEKI LKLPKEEDSA NLKPSELKKD TCYSPKPSVY LSTPSSASKA NTTAFLTPLE IKAKVETDDV KKNSLDELRA QIIELLCIVE ALKKDHGKEL
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 82%.
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; mesenchyme to epithelium transition protein, SH3 domains; Mesenchyme-to-epithelium transition protein with SH3 domains 1; METS-1; SH3 domain-containing adapter protein; SH3 domain-containing adaptor protein METS-1
Gene Aliases: AL024079; C78928; CD2AP; CMS; METS-1; Mets1
Molecular Function: signaling molecule