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Invitrogen
CD2AP Polyclonal Antibody
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Product Details
PA5-51894
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CD2AP. Recombinant protein control fragment (Product #RP-101068).
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VDFDSLTVRT SKETDVVNFD DIASSENLLH LTANRPKMPG RRLPGRFNGG HSPTHSPEKI LKLPKEEDSA NLKPSELKKD TCYSPKPSVY LSTPSSASKA NTTAFLTPLE IKAKVETDDV KKNSLDELRA QIIELLCIVE ALKKDHGKEL
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 82%.
Target Information
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology (SH) 3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; mesenchyme to epithelium transition protein, SH3 domains; Mesenchyme-to-epithelium transition protein with SH3 domains 1; METS-1; SH3 domain-containing adapter protein; SH3 domain-containing adaptor protein METS-1
Gene Aliases: AL024079; C78928; CD2AP; CMS; METS-1; Mets1
UniProt ID: (Human) Q9Y5K6, (Mouse) Q9JLQ0, (Rat) F1LRS8
Entrez Gene ID: (Human) 23607, (Mouse) 12488, (Rat) 316258
actin binding
structural constituent of cytoskeleton
protein binding
SH3 domain binding
clathrin binding
phosphatidylinositol 3-kinase regulatory subunit binding
identical protein binding
cadherin binding
actin filament binding
vascular endothelial growth factor receptor binding
beta-catenin binding
protein C-terminus binding
protein complex binding
cell cycle
mitotic nuclear division
vesicle organization
single organismal cell-cell adhesion
cell migration
negative regulation of transforming growth factor beta1 production
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of receptor-mediated endocytosis
cell division
positive regulation of protein localization to nucleus
regulation of actin cytoskeleton reorganization
immunological synapse formation
kidney development
liver development
endothelium development
lipid metabolic process
apoptotic process
substrate-dependent cell migration, cell extension
inflammatory response
response to oxidative stress
actin filament organization
signal transduction
cell proliferation
male gonad development
protein secretion
response to wounding
response to virus
gene expression
protein transport
actin filament polymerization
cell differentiation
protein catabolic process
neuron projection development
Rab protein signal transduction
glomerulus development
response to insulin
transforming growth factor beta1 production
regulation of actin cytoskeleton organization
maintenance of blood-brain barrier
neurotrophin signaling pathway
nerve growth factor signaling pathway
protein kinase B signaling
negative regulation of neuron apoptotic process
cell-cell adhesion mediated by cadherin
cell-cell junction organization
glucose import
filopodium assembly
neurotrophin TRK receptor signaling pathway
regulation of synaptic plasticity
lymph node development
collateral sprouting
positive regulation of protein secretion
synapse organization
T cell receptor signaling pathway
negative regulation of small GTPase mediated signal transduction
protein heterooligomerization
stress-activated MAPK cascade
localization of cell
adipose tissue development
membrane organization
protein-containing complex assembly
ERK1 and ERK2 cascade
response to transforming growth factor beta
glomerular visceral epithelial cell differentiation
renal albumin absorption
response to glial cell derived neurotrophic factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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