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Invitrogen

CD3/CD19 Antibody Cocktail, FITC, PE

View all (4) CD3/CD19 antibodies

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Product Details

MA1-12087

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Cocktail

Type

Antibody

Clone

M2AB, 1G9

Immunogen

human thymocytes

Conjugate

FITC , PE FITC , PE FITC , PE

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.2% carrier protein

Contains

0.08% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1071959

Product Specific Information

This antibody is a monoclonal mixture of FITC-conjugated CD3 (clone M2AB, isotype IgG1) and PE-conjugated CD19 (clone 1G9, isotype IgG1).

Target Information

CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CD19; CD19 differentiation antigen; CD247; CD247 antigen, zeta subunit; CD3 antigen, delta subunit; CD3 delta; CD3 epsilon; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; component of the TCR/CD3 complex; Differentiation antigen CD19; FLJ18683; OKT3, delta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen Leu-12; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; TCR zeta; TCR zeta chain; tissue factor-targeting CAR1 dimer; tissue factor-targeting CAR1 monomer; unnamed protein product

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Gene Aliases: B4; CD19; CD247; CD3-DELTA; CD3-GAMMA; CD3-ZETA; CD3D; CD3DELTA; CD3E; CD3epsilon; CD3G; CD3GAMMA; CD3H; CD3Q; CD3Z; CD3ZETA; CVID3; IMD17; IMD18; IMD19; IMD25; T3D; T3E; T3G; T3Z; TCRE; TCRZ

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UniProt ID: (Human) P15391, (Human) P20963, (Human) P04234, (Human) P07766, (Human) P09693

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Entrez Gene ID: (Human) 930, (Human) 919, (Human) 915, (Human) 916, (Human) 917

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Function(s)
transmembrane signaling receptor activity protein binding identical protein binding protein homodimerization activity protein heterodimerization activity protein tyrosine kinase binding SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding
Process(es)
B-1 B cell differentiation adaptive immune response B cell proliferation involved in immune response immune system process immunoglobulin mediated immune response B cell mediated immunity B cell proliferation antigen receptor-mediated signaling pathway B cell receptor signaling pathway regulation of B cell receptor signaling pathway regulation of B cell activation positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling cell surface receptor signaling pathway Fc-gamma receptor signaling pathway gamma-delta T cell activation alpha-beta T cell activation T cell receptor signaling pathway protein oligomerization protein-containing complex assembly positive regulation of protein localization to cell surface positive thymic T cell selection establishment or maintenance of cell polarity protein transport T cell activation regulation of lymphocyte apoptotic process positive regulation of cell-matrix adhesion positive regulation of T cell anergy T cell anergy transmembrane receptor protein tyrosine kinase signaling pathway signal complex assembly G-protein coupled receptor signaling pathway smoothened signaling pathway regulation of signal transduction positive regulation of gene expression negative regulation of gene expression dendrite development calcium-mediated signaling cerebellum development T cell costimulation positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-4 production positive regulation of cell-cell adhesion mediated by integrin CD4-positive, alpha-beta T cell proliferation T cell proliferation positive regulation of T cell proliferation regulation of apoptotic process positive regulation of MAPK cascade negative thymic T cell selection negative regulation of smoothened signaling pathway lymphocyte activation positive regulation of calcium-mediated signaling positive regulation of T cell activation apoptotic signaling pathway positive regulation of CD4-positive, alpha-beta T cell proliferation
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