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|Tested species reactivity||Human, Primate|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human infant thymocytes and lymphocytes from a patient with Sezary Syndrome.|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/50 - 1/100|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01 EU/ug.
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus.
MA1-80537 was used in flow cytometry to examine the antibody repertoire of patients with acute systemic lupus erythematosus.
|Tipton CM,Fucile CF,Darce J,Chida A,Ichikawa T,Gregoretti I,Schieferl S,Hom J,Jenks S,Feldman RJ,Mehr R,Wei C,Lee FE,Cheung WC,Rosenberg AF,Sanz I||Nature immunology (16:755)||2015|
B cell antigen receptor signaling enhances IFN-gamma-induced Stat1 target gene expression through calcium mobilization and activation of multiple serine kinase pathways.
MA1-80537 was used in flow cytometry to study the mechanism by which B cell antigen receptor signaling enhances IFN-gamma-induced Stat1 target gene expression
|Xu W,Nair JS,Malhotra A,Zhang JJ||Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (25:113)||2005|
Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis.
MA1-80537 was used in immunohistochemistry to identify novel disease-specific pathways in spondylarthritis synovitis using geneome-wide microarray analysis
|Yeremenko N,Noordenbos T,Cantaert T,van Tok M,van de Sande M,Cañete JD,Tak PP,Baeten D||Arthritis and rheumatism (65:174)||2013|
Retention of unassembled components of integral membrane proteins by calnexin.
MA1-80537 was used in immunoprecipitation to investigate calnexin's interaction with incompletely assembled TCR components
|Rajagopalan S,Xu Y,Brenner MB||Science (New York, N.Y.) (263:387)||1994|
CD3-epsilon; CD3e antigen; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); epsilon polypeptide TiT3 complex; epsilon subunit of T3; FLJ18683; T-cell antigen receptor complex; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; TCRE
CD3E; IMD18; T3E; TCRE