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FIGURE: 1 / 1
CD4 Antibody (MA5-28361) in Flow
Flow cytometry of CD4 in red cell lysed bovine blood. Sample was incubated with CD4 monoclonal antibody (Product # MA5-28361) and gated on lymphocytes. Figures are arranged as follows: A) FITC conjugated mouse anti bovine CD2 and Alexa Fluor 647 conjugated mouse IgG2a isotype control. B) FITC conjugated mouse anti bovine CD2 and Alexa Fluor 647 conjugated mouse anti bovine CD4.
Product Details
MA5-28361
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
CC8
Immunogen
Bovine lymphocytes
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745324
Product Specific Information
This antibody recognizes bovine CD4, the homolog of human CD4 and immunoprecipitates approximately a 50 kDa molecule. The phenotype, tissue distribution and function of T-cells expressing the bovine CD4 antigen are similar to those in other species. However, expression on macrophages has not yet been detected.
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD4 antigen; CD4 antigen p55; cd4a; fCD4; Leu-3
Entrez Gene ID: (Bovine) 407098
Performance Guarantee
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