Proteintech

CD44 Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Product Image Gallery

CD44 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 15675-1-AP (CD44 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CD44 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 15675-1-AP (CD44 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CD44 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA)) — Immunofluorescent analysis of (4% PFA) fixed human colon cancer tissue using 15675-1-AP (CD44 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

CD44 Antibody in Western Blot (WB) — Mouse thymus tissue were subjected to SDS PAGE followed by western blot with 15675-1-AP (CD44 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CD44 Antibody in Flow Cytometry (Flow) — 1X10^6 HeLa cells were stained with 0.2ug CD44 antibody (15675-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488 -Goat anti-Rabbit IGG with dilution 1:100.

CD44 Antibody in Immunoprecipitation (IP) — IP result of anti-CD44 (IP:15675-1-AP, 4ug; Detection:15675-1-AP 1:2000) with HeLa cells lysate 2400ug.

Product Details

15675-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 46 publications 46 publications
Immunohistochemistry (IHC)	-	View 18 publications 18 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:100-1:500	-
Immunohistochemistry (PFA fixed) (IHC (PFA))	1:100-1:200	-
Immunocytochemistry (ICC/IF)	1:100-1:200	View 10 publications 10 publications
Flow Cytometry (Flow)	0.2 µg/1x10^6 cells	View 1 publication 1 publication
Immunoprecipitation (IP)	0.5-4.0 µg	-
Miscellaneous PubMed (Misc)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Bovine, Deer, Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CD44 Fusion Protein Ag8143 (28-380 aa encoded by BC004372) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.27 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: CRFAGVFHV EKNGRYSISR TEAADLCKAF NSTLPTMAQM EKALSIGFET CRYGFIEGHV VIPRIHPNSI CAANNTGVYI LTSNTSQYDT YCFNASAPPE EDCTSVTDLP NAFDGPITIT IVNRDGTRYV QKGEYRTNPE DIYPSNPTDD DVSSGSSSER SSTSGGYIFY TFSTVHPIPD EDSPWITDST DRIPATSTSS NTISAGWEPN EENEDERDRH LSFSGSGIDD DEDFISSTIS TTPRAFDHTK QNQDWTQWNP SHSNPEVLLQ TTTRMTDVDR NGTTAYEGNW NPEAHPPLIH HEHHEEEETP HSTSTIQATP SSTTEETATQ KEQWFGNRWH EGYRQTPRED SHST (28-380 aa encoded by BC004372)

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC.

Frontiers in physiology

Liu L,Zhao X,Zou H,Bai R,Yang K,Tian Z

Mon Mar 21 00:00:00 EDT 2022

CD44 is overexpressed and correlated with tumor progression in gallbladder cancer.

Cancer management and research

He Y,Xue C,Yu Y,Chen J,Chen X,Ren F,Ren Z,Cui G,Sun R

Mon Mar 21 00:00:00 EDT 2022

CD44 is overexpressed and correlated with tumor progression in gallbladder cancer.

Cancer management and research

He Y,Xue C,Yu Y,Chen J,Chen X,Ren F,Ren Z,Cui G,Sun R

Mon Mar 21 00:00:00 EDT 2022

Fentanyl Promotes Breast Cancer Cell Stemness and Epithelial-Mesenchymal Transition by Upregulating α1, 6-Fucosylation via Wnt/β-Catenin Signaling Pathway.

Frontiers in physiology

Yang HF,Yu M,Jin HD,Yao JQ,Lu ZL,Yabasin IB,Yan Q,Wen QP

Wed Sep 30 00:00:00 EDT 2020

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19.

Theranostics

Ren J,Ding L,Zhang D,Shi G,Xu Q,Shen S,Wang Y,Wang T,Hou Y

Mon Aug 26 00:00:00 EDT 2019

Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.

International journal of food sciences and nutrition

Ge M,Zhang L,Cao L,Xie C,Li X,Li Y,Meng Y,Chen Y,Wang X,Chen J,Zhang Q,Shao J,Zhong C

Thu Aug 01 00:00:00 EDT 2019

In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin.

Pharmaceutical development and technology

Xie MH,Ge M,Peng JB,Jiang XR,Wang DS,Ji LQ,Ying Y,Wang Z

Sat Jun 01 00:00:00 EDT 2019

MicroRNA-135a-5p promotes neuronal differentiation of pluripotent embryonal carcinoma cells by repressing Sox6/CD44 pathway.

Biochemical and biophysical research communications

Li W,Fang J,Shen J,Liu X,Hou J,Zhu Y,Ma X

Tue Feb 05 00:00:00 EST 2019

Osterix promotes the migration and angiogenesis of breast cancer by upregulation of S100A4 expression.

Journal of cellular and molecular medicine

Qu S,Wu J,Bao Q,Yao B,Duan R,Chen X,Li L,Yuan H,Jin Y,Ma C

Fri Feb 01 00:00:00 EST 2019

Osterix promotes the migration and angiogenesis of breast cancer by upregulation of S100A4 expression.

Journal of cellular and molecular medicine

Qu S,Wu J,Bao Q,Yao B,Duan R,Chen X,Li L,Yuan H,Jin Y,Ma C

Fri Feb 01 00:00:00 EST 2019

Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer.

Journal of molecular medicine (Berlin, Germany)

Yuan W,Ji J,Shu Y,Chen J,Liu S,Wu L,Zhou Z,Liu Z,Tang Q,Zhang X,Shu X

Tue Jan 01 00:00:00 EST 2019

BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.

Redox biology

Zhao X,Zheng F,Li Y,Hao J,Tang Z,Tian C,Yang Q,Zhu T,Diao C,Zhang C,Chen M,Hu S,Guo P,Zhang L,Liao Y,Yu W,Chen M,Zou L,Guo W,Deng W

Tue Jan 01 00:00:00 EST 2019

BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.

Redox biology

Zhao X,Zheng F,Li Y,Hao J,Tang Z,Tian C,Yang Q,Zhu T,Diao C,Zhang C,Chen M,Hu S,Guo P,Zhang L,Liao Y,Yu W,Chen M,Zou L,Guo W,Deng W

Tue Jan 01 00:00:00 EST 2019

High-resolution acoustophoretic 3D cell patterning to construct functional collateral cylindroids for ischemia therapy.

Nature communications

Kang B,Shin J,Park HJ,Rhyou C,Kang D,Lee SJ,Yoon YS,Cho SW,Lee H

Thu Dec 20 00:00:00 EST 2018

Endogenous and exogenous galectin-3 promote the adhesion of tumor cells with low expression of MUC1 to HUVECs through upregulation of N-cadherin and CD44.

Laboratory investigation; a journal of technical methods and pathology

Cao Z,Hao Z,Xin M,Yu L,Wang L,Zhang Y,Zhang X,Guo X

Sat Dec 01 00:00:00 EST 2018

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability.

Biochemistry and biophysics reports

Lu Y,Maruyama J,Kuwata K,Fukuda H,Iwasa H,Arimoto-Matsuzaki K,Sugimura H,Hata Y

Sat Dec 01 00:00:00 EST 2018

Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.

Journal of experimental zoology. Part B, Molecular and developmental evolution

Zhao XX,An XL,Zhu XC,Jiang Y,Zhai YH,Zhang S,Cai NN,Tang B,Li ZY,Zhang XM

Sat Dec 01 00:00:00 EST 2018

Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.

Phytotherapy research : PTR

Chen Y,Li Y,Wang XQ,Meng Y,Zhang Q,Zhu JY,Chen JQ,Cao WS,Wang XQ,Xie CF,Li XT,Geng SS,Wu JS,Zhong CY,Han HY

Sat Dec 01 00:00:00 EST 2018

Proteomic Analysis of Plasma Membrane Proteins of Antler Stem Cells Using Label-Free LC⁻MS/MS.

International journal of molecular sciences

Wang D,Ba H,Li C,Zhao Q,Li C

Mon Nov 05 00:00:00 EST 2018

Isobavachalcone sensitizes cells to E2-induced paclitaxel resistance by down-regulating CD44 expression in ER+ breast cancer cells.

Journal of cellular and molecular medicine

Shi J,Chen Y,Chen W,Tang C,Zhang H,Chen Y,Yang X,Xu Z,Wei J,Chen J

Thu Nov 01 00:00:00 EDT 2018

Isobavachalcone sensitizes cells to E2-induced paclitaxel resistance by down-regulating CD44 expression in ER+ breast cancer cells.

Journal of cellular and molecular medicine

Shi J,Chen Y,Chen W,Tang C,Zhang H,Chen Y,Yang X,Xu Z,Wei J,Chen J

Thu Nov 01 00:00:00 EDT 2018

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients.

Journal of experimental & clinical cancer research : CR

Zhang J,Cai H,Sun L,Zhan P,Chen M,Zhang F,Ran Y,Wan J

Wed Sep 12 00:00:00 EDT 2018

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients.

Journal of experimental & clinical cancer research : CR

Zhang J,Cai H,Sun L,Zhan P,Chen M,Zhang F,Ran Y,Wan J

Wed Sep 12 00:00:00 EDT 2018

Tumor suppressor LKB1 inhibits the progression of gallbladder carcinoma and predicts the prognosis of patients with this malignancy.

International journal of oncology

Hu MT,Wang JH,Yu Y,Liu C,Li B,Cheng QB,Jiang XQ

Sat Sep 01 00:00:00 EDT 2018

CD44-targeted hyaluronic acid-curcumin prodrug protects renal tubular epithelial cell survival from oxidative stress damage.

Carbohydrate polymers

Hu JB,Li SJ,Kang XQ,Qi J,Wu JH,Wang XJ,Xu XL,Ying XY,Jiang SP,You J,Du YZ

Wed Aug 01 00:00:00 EDT 2018

miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness.

Theranostics

Zhang Q,Zhuang J,Deng Y,Yang L,Cao W,Chen W,Lin T,Lv X,Yu H,Xue Y,Guo H

Mon Jul 09 00:00:00 EDT 2018

miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness.

Theranostics

Zhang Q,Zhuang J,Deng Y,Yang L,Cao W,Chen W,Lin T,Lv X,Yu H,Xue Y,Guo H

Mon Jul 09 00:00:00 EDT 2018

Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.

Cancer chemotherapy and pharmacology

Zhang Q,Li XT,Chen Y,Chen JQ,Zhu JY,Meng Y,Wang XQ,Li Y,Geng SS,Xie CF,Wu JS,Zhong CY,Han HY

Fri Jun 01 00:00:00 EDT 2018

Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.

Acta biochimica et biophysica Sinica

Song L,Chen X,Wang P,Gao S,Qu C,Liu L

Fri Jun 01 00:00:00 EDT 2018

Studying the mechanism of PLAGL2 overexpression and its carcinogenic characteristics based on 3'-untranslated region in colorectal cancer.

International journal of oncology

Su C,Li D,Li N,Du Y,Yang C,Bai Y,Lin C,Li X,Zhang Y

Tue May 01 00:00:00 EDT 2018

Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.

Journal of cellular biochemistry

Li X,Meng Y,Xie C,Zhu J,Wang X,Li Y,Geng S,Wu J,Zhong C,Li M

Tue May 01 00:00:00 EDT 2018

Histochemical evidence of IGF2 mRNA-binding protein 2-mediated regulation of osteoclast function and adhesive ability.

Histochemistry and cell biology

Liu H,Li D,Liu S,Liu Z,Li M

Sun Apr 01 00:00:00 EDT 2018

A Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Gong Q,Zou R,Xing J,Xiang L,Zhang R,Wu A

Sun Apr 01 00:00:00 EDT 2018

Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway.

Oncogenesis

Qian W,Kong X,Zhang T,Wang D,Song J,Li Y,Li X,Geng H,Min J,Kong Q,Liu J,Liu Z,Wang D,Zhang Z,Yu D,Zhong C

Tue Mar 13 00:00:00 EDT 2018

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.

Cancer letters

Wang J,Tian L,Khan MN,Zhang L,Chen Q,Zhao Y,Yan Q,Fu L,Liu J

Wed Feb 28 00:00:00 EST 2018

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.

Cancer letters

Wang J,Tian L,Khan MN,Zhang L,Chen Q,Zhao Y,Yan Q,Fu L,Liu J

Wed Feb 28 00:00:00 EST 2018

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system.

Scientific reports

Saito Y,Nakaoka T,Muramatsu T,Ojima H,Sukeda A,Sugiyama Y,Uchida R,Furukawa R,Kitahara A,Sato T,Kanai Y,Saito H

Mon Feb 12 00:00:00 EST 2018

β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Yu W,Li L,Zheng F,Yang W,Zhao S,Tian C,Yin W,Chen Y,Guo W,Zou L,Deng W

Thu Jan 18 00:00:00 EST 2018

Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.

Oncotarget

Wei X,Ye J,Shang Y,Chen H,Liu S,Liu L,Wang R

Tue Dec 12 00:00:00 EST 2017

Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.

Biochemical and biophysical research communications

Wang D,Kong X,Li Y,Qian W,Ma J,Wang D,Yu D,Zhong C

Sat Nov 04 00:00:00 EDT 2017

Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.

Biochemical and biophysical research communications

Wang D,Kong X,Li Y,Qian W,Ma J,Wang D,Yu D,Zhong C

Sat Nov 04 00:00:00 EDT 2017

SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer.

Scientific reports

Wu DM,Liu T,Deng SH,Han R,Xu Y

Thu Aug 03 00:00:00 EDT 2017

SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer.

Scientific reports

Wu DM,Liu T,Deng SH,Han R,Xu Y

Thu Aug 03 00:00:00 EDT 2017

S100P is associated with proliferation and migration in nasopharyngeal carcinoma.

Oncology letters

Liu Y,Wang C,Shan X,Wu J,Liu H,Liu H,Zhang J,Xu W,Sha Z,He J,Fan J

Sat Jul 01 00:00:00 EDT 2017

DACH1 suppresses breast cancer as a negative regulator of CD44.

Scientific reports

Xu H,Yu S,Yuan X,Xiong J,Kuang D,Pestell RG,Wu K

Wed Jun 28 00:00:00 EDT 2017

DACH1 suppresses breast cancer as a negative regulator of CD44.

Scientific reports

Xu H,Yu S,Yuan X,Xiong J,Kuang D,Pestell RG,Wu K

Wed Jun 28 00:00:00 EDT 2017

(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.

Nutrients

Chen Y,Wang XQ,Zhang Q,Zhu JY,Li Y,Xie CF,Li XT,Wu JS,Geng SS,Zhong CY,Han HY

Sat Jun 03 00:00:00 EDT 2017

miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.

The Journal of nutritional biochemistry

Zhu J,Wang S,Chen Y,Li X,Jiang Y,Yang X,Li Y,Wang X,Meng Y,Zhu M,Ma X,Huang C,Wu R,Xie C,Geng S,Wu J,Zhong C,Han H

Thu Jun 01 00:00:00 EDT 2017

Adipocytes enhance expression of osteoclast adhesion-related molecules through the CXCL12/CXCR4 signalling pathway.

Cell proliferation

Luo T,Liu H,Feng W,Liu D,Du J,Sun J,Wang W,Han X,Guo J,Amizuka N,Li X,Li M

Thu Jun 01 00:00:00 EDT 2017

Sulfiredoxin May Promote Cervical Cancer Metastasis via Wnt/β-Catenin Signaling Pathway.

International journal of molecular sciences

Lan K,Zhao Y,Fan Y,Ma B,Yang S,Liu Q,Linghu H,Wang H

Thu Apr 27 00:00:00 EDT 2017

Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.

Phytotherapy research : PTR

Zhu JY,Yang X,Chen Y,Jiang Y,Wang SJ,Li Y,Wang XQ,Meng Y,Zhu MM,Ma X,Huang C,Wu R,Xie CF,Li XT,Geng SS,Wu JS,Zhong CY,Han HY

Sat Apr 01 00:00:00 EDT 2017

CD44+ cancer cell-induced metastasis: A feasible neck metastasis model.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Wu TF,Chen L,Bu LL,Gao J,Zhang WF,Jia J

Sat Apr 01 00:00:00 EDT 2017

CD44+ cancer cell-induced metastasis: A feasible neck metastasis model.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Wu TF,Chen L,Bu LL,Gao J,Zhang WF,Jia J

Sat Apr 01 00:00:00 EDT 2017

Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.

Biochemical and biophysical research communications

Zhu J,Jiang Y,Yang X,Wang S,Xie C,Li X,Li Y,Chen Y,Wang X,Meng Y,Zhu M,Wu R,Huang C,Ma X,Geng S,Wu J,Zhong C

Sun Jan 01 00:00:00 EST 2017

Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis.

Cell death & disease

Chu Q,Huang H,Huang T,Cao L,Peng L,Shi S,Zheng L,Xu L,Zhang S,Huang J,Li X,Qian C,Huang B

Thu Nov 03 00:00:00 EDT 2016

CD44 correlates with clinicopathological characteristics and is upregulated by EGFR in breast cancer.

International journal of oncology

Xu H,Wu K,Tian Y,Liu Q,Han N,Yuan X,Zhang L,Wu GS,Wu K

Sat Oct 01 00:00:00 EDT 2016

CD44 correlates with clinicopathological characteristics and is upregulated by EGFR in breast cancer.

International journal of oncology

Xu H,Wu K,Tian Y,Liu Q,Han N,Yuan X,Zhang L,Wu GS,Wu K

Sat Oct 01 00:00:00 EDT 2016

MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.

Scientific reports

Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

Tue Sep 06 00:00:00 EDT 2016

MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.

Scientific reports

Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

Tue Sep 06 00:00:00 EDT 2016

MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer.

Journal of ovarian research

Vos MC,Hollemans E,Ezendam N,Feijen H,Boll D,Pijlman B,van der Putten H,Klinkhamer P,van Kuppevelt TH,van der Wurff AA,Massuger LF

Fri Sep 02 00:00:00 EDT 2016

EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loop.

Oncogene

Yang CF,Yang GD,Huang TJ,Li R,Chu QQ,Xu L,Wang MS,Cai MD,Zhong L,Wei HJ,Huang HB,Huang JL,Qian CN,Huang BJ

Thu Jun 30 00:00:00 EDT 2016

NIBP impacts on the expression of E-cadherin, CD44 and vimentin in colon cancer via the NF-κB pathway.

Molecular medicine reports

Xu CY,Qin MB,Tan L,Liu SQ,Huang JA

Wed Jun 01 00:00:00 EDT 2016

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.

Scientific reports

Zhao ZL,Zhang L,Huang CF,Ma SR,Bu LL,Liu JF,Yu GT,Liu B,Gutkind JS,Kulkarni AB,Zhang WF,Sun ZJ

Mon Apr 25 00:00:00 EDT 2016

Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice.

International journal of clinical and experimental pathology

Peng Z,Chen W,Wang L,Ye Z,Gao S,Sun X,Guo Z

Tue Mar 22 00:00:00 EDT 2016

KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.

Scientific reports

Li L,Duan T,Wang X,Zhang RH,Zhang M,Wang S,Wang F,Wu Y,Huang H,Kang T

Fri Feb 05 00:00:00 EST 2016

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.

Oncotarget

Han S,Guo J,Liu Y,Zhang Z,He Q,Li P,Zhang M,Sun H,Li R,Li Y,Zeng W,Liu J,Lian L,Gao Y,Shen L

Tue Dec 29 00:00:00 EST 2015

Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.

Oncotarget

Han S,Guo J,Liu Y,Zhang Z,He Q,Li P,Zhang M,Sun H,Li R,Li Y,Zeng W,Liu J,Lian L,Gao Y,Shen L

Tue Dec 29 00:00:00 EST 2015

Vorinostat protects against calcium oxalate-induced kidney injury in mice.

Molecular medicine reports

Wang L,Chen W,Peng Z,Liu C,Zhang C,Guo Z

Tue Sep 01 00:00:00 EDT 2015

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells.

The Journal of experimental medicine

Kang DW,Choi CY,Cho YH,Tian H,Di Paolo G,Choi KY,Min do S

Mon Jul 27 00:00:00 EDT 2015

Histochemical evidence of zoledronate inhibiting c-src expression and interfering with CD44/OPN-mediated osteoclast adhesion in the tibiae of mice.

Journal of molecular histology

Liu H,Cui J,Sun J,Du J,Feng W,Sun B,Li J,Han X,Liu B,Oda K,Amizuka N,Li M

Mon Jun 01 00:00:00 EDT 2015

CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma.

BioMed research international

He KF,Zhang L,Huang CF,Ma SR,Wang YF,Wang WM,Zhao ZL,Liu B,Zhao YF,Zhang WF,Sun ZJ

Mon Jan 05 00:00:00 EST 2015

Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer.

BMC cancer

Lim S,Yoo BK,Kim HS,Gilmore HL,Lee Y,Lee HP,Kim SJ,Letterio J,Lee HG

Wed Dec 10 00:00:00 EST 2014

Correlation of ALDH1, CD44, OCT4 and SOX2 in tongue squamous cell carcinoma and their association with disease progression and prognosis.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Huang CF,Xu XR,Wu TF,Sun ZJ,Zhang WF

Fri Aug 01 00:00:00 EDT 2014

Expression and clinical significance of colorectal cancer stem cell marker EpCAM^high/CD44⁺ in colorectal cancer.

Oncology letters

Liu D,Sun J,Zhu J,Zhou H,Zhang X,Zhang Y

Thu May 01 00:00:00 EDT 2014

Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.

Cancer letters

Yang CF,Peng LX,Huang TJ,Yang GD,Chu QQ,Liang YY,Cao X,Xie P,Zheng LS,Huang HB,Cai MD,Huang JL,Liu RY,Zhu ZY,Qian CN,Huang BJ

Fri Mar 28 00:00:00 EDT 2014

Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.

Cancer letters

Yang CF,Peng LX,Huang TJ,Yang GD,Chu QQ,Liang YY,Cao X,Xie P,Zheng LS,Huang HB,Cai MD,Huang JL,Liu RY,Zhu ZY,Qian CN,Huang BJ

Fri Mar 28 00:00:00 EDT 2014

Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells.

Small (Weinheim an der Bergstrasse, Germany)

Kingham E,White K,Gadegaard N,Dalby MJ,Oreffo RO

Mon Jun 24 00:00:00 EDT 2013

Wentilactone B from Aspergillus wentii induces apoptosis and inhibits proliferation and migration of human hepatoma SMMC-7721 cells.

Biological & pharmaceutical bulletin

Zhang Z,Miao L,Sun W,Jiao B,Wang B,Yao L,Huang C

Thu Apr 04 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; Cell surface glycoprotein CD44 (hyaluronate binding protein); chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44

Gene Aliases: AU023126; AW121933; AW146109; CD44; CD44A; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; METAA; MIC4; Pgp-1; Pgp1; RHAMM

UniProt ID: (Human) P16070, (Mouse) P15379, (Rat) P26051

Entrez Gene ID: (Human) 960, (Mouse) 12505, (Rat) 25406

Molecular Function: transmembrane signal receptor