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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Immunogen||Myeloid cell line M1 induced with 1x10-5 M dexamethazone.|
|Conjugate||Alexa Fluor® 405|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.1-0.25 µg per 1x10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells.
RM5726 was used in flow cytometry to characterize mice that constitutively expresses the GITR ligand on APCs.
|Carrier Y,Whitters MJ,Miyashiro JS,LaBranche TP,Ramon HE,Benoit SE,Ryan MS,Keegan SP,Guay H,Douhan J,Collins M,Dunussi-Joannopoulos K,Medley QG||European journal of immunology (42:1393)||2012|
CD44; CD44 antigen; Cell surface glycoprotein CD44; ECMR-III; Extracellular matrix receptor III; GP90 lymphocyte homing adhesion receptor; GP90 lymphocyte homing/adhesion receptor; Hermes antigen; HUTCH-I; hyaluronate binding protein; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I
AU023126; AW121933; AW146109; Cd44; HERMES; Ly-24; Pgp-1