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Invitrogen
CD56 Monoclonal Antibody (RNL-1)
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FIGURE: 1 / 4
CD56 Antibody (MA1-06800) in ICC/IF
Immunofluorescence analysis of CD56 was performed using 70% confluent log phase IMR-32 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with CD56 Monoclonal Antibody (RNL-1) (Product # MA1-06800) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 647 (Product... View More
Product Details
MA1-06800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
RNL-1
Immunogen
Small cell lung cancer cell line NCI-H82.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-06800 detects NCAM in human and mouse samples.
MA1-06800 has sucessfully been used in immunohistochemistry and immunocytochemistry procedures.
The MA1-06800 immunogen is a membrane preparation of the small cell lung cancer cell line NCI-H82.
Store at 4°C or in small aliquots at -20°C.
Target Information
CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 145 kda neural cell adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; CD-56; CD56; E NCAM; membrane glycoprotein; N CAM1; N-CAM; N-CAM-1; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule secreted isoform; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM; unnamed protein product
Gene Aliases: CD56; E-NCAM; MSK39; NCAM; NCAM-1; NCAM1
UniProt ID: (Human) P13591, (Mouse) P13595
Entrez Gene ID: (Human) 4684, (Mouse) 17967
regulation of exocyst assembly
cell adhesion
cell surface receptor signaling pathway
aging
learning or memory
response to lead ion
response to fluoxetine
thalamus development
neuron projection development
multicellular organismal response to stress
homotypic cell-cell adhesion
response to cocaine
neuron development
positive regulation of calcium-mediated signaling
regulation of sensory perception of pain
positive regulation of cardiac muscle cell proliferation
negative regulation of cell death
epithelial to mesenchymal transition
viral entry into host cell
commissural neuron axon guidance
regulation of semaphorin-plexin signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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