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Invitrogen
CD8 Monoclonal Antibody (RIV11)
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FIGURE: 1 / 1
CD8 Antibody (MA1-7632) in IHC (P)
Discover oncology 2024 -
The impact of CLDN1 and EGFR silencing on tumor formation ability of PTC cells and CD8 + T cell immune function. A Morphology of mouse tumor tissues in each group; B volume of mouse tumor tissues in each group; C weight of mouse tumor tissues in each group; D WB analysis of the expression of proteins related to the TGF-beta receptor signaling pathway in the EMT process in mouse tumor tissues, including TGFb... View More
Product Details
MA1-7632
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
RIV11
Immunogen
CD8, Human white blood cell fraction
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.2
Contains
0.01% sodium azide
Storage conditions
4°C short term, -80°C long term
RRID
Product Specific Information
MA1-7632 detects CD8 from human and mouse samples.
MA1-7632 has been successfully used in ELISA, flow cytometry, immunoprecipitation, and immunohistochemistry (frozen sections) procedures.
The MA1-7632 immunogen is a CD8 protein.
Target Information
CD8, also known as cluster of differentiation 8, is a type I transmembrane glycoprotein of the immunoglobulin family that plays a crucial role in T cell differentiation, activation, and signal transduction. It is expressed as either a heterodimer (CD8 alpha beta) or a homodimer (CD8 alpha alpha). The CD8 alpha beta form is predominantly found on the majority of thymocytes and a subpopulation of mature alpha beta TCR T cells, while the CD8 alpha alpha form is expressed on gamma delta TCR T cells, a subset of intestinal intraepithelial lymphocytes (IELs), and dendritic cells. CD8 functions as a co-receptor for major histocompatibility complex class I (MHC-I) molecules, working alongside the T cell receptor (TCR). The CD8 alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes, and dendritic cells as disulfide-linked homodimers of CD8 alpha. Upon ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), CD8 recruits lymphocyte-specific protein tyrosine kinase (Lck), leading to lymphokine production, increased motility, and activation of cytotoxic T lymphocytes (CTLs). Activated CTLs are vital for clearing pathogens and tumor cells. The differentiation of naive CD8+ T cells into CTLs is strongly enhanced by cytokines such as IL-2, IL-12, and TGF-beta1. Through its interactions with MHC-I and association with protein tyrosine kinase p56lck, CD8 plays a significant role in T cell development and the activation of mature T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a; CD8a molecule; CD8alpha; CD8b; CD8b molecule; CD8beta; cell surface glycoprotein T8 precursor; fCD8; Leu-2; leu-2a; Leu2 T-lymphocyte antigen; Ly-3 homolog; Lymphocyte antigen 3; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); OKT8 T-cell antigen; T cell co-receptor; T lymphocyte surface glycoprotein (CD8-beta) precursor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-cell differentiation antigen Leu-2/T8; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen; unnamed protein product
Gene Aliases: BB154331; CD8; CD8A; CD8alpha; CD8B; CD8B1; CD8beta; IMD116; LEU2; Ly-2; Ly-3; Ly-35; Ly-B; Ly-C; LY3; Lyt-2; Lyt-3; Lyt2; LYT3; MAL; p32; P37
UniProt ID: (Human) P01732, (Human) P10966, (Mouse) P01731, (Mouse) P10300
Entrez Gene ID: (Human) 925, (Human) 926, (Mouse) 12525, (Mouse) 12526
adaptive immune response
immune system process
T cell mediated immunity
immune response
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
antigen processing and presentation
T cell activation
cytotoxic T cell differentiation
T cell receptor signaling pathway
regulation of immune response
positive regulation of calcium-mediated signaling
defense response to virus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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