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CDC25C Polyclonal Antibody

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Antibody Testing Data (9)

CDC25C Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

CDC25C Antibody (16485-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue slide using (Product # 16485-1-AP) CDC25C antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CDC25C Antibody in Flow Cytometry (Flow)

CDC25C Antibody in Immunoprecipitation (IP)

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Product Details

16485-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDC25C Fusion Protein Ag9607 (1-279 aa encoded by BC019089)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSTELFSST REEGSSGSGP SFRSNQRKML NLLLERDTSF TVCPDVPRTP VGKFLGDSAN LSILSGGTPK CCLDLSNLSS GEITATQLTT SADLDETGHL DSSGLQEVHL AGMNHDQHLM KCSPAQLLCS TPNGLDRGHR KRDAMCSSSA NKENDNGNLV DSEMKYLGSP ITTVPKLDKN PNLGEDQAEE ISDELMEFSL KDQEAKVSRS GLYRSPSMPE NLNRPRLKQV EKFKDNTIPD KVKKKYFSGQ GKLRKGLCLK KTVSLCDITI TQMLEEDSNQ (1-279 aa encoded by BC019089)

Target Information

M-phase inducer phosphatase 3is an enzyme that in humans is encoded by theCDC25Cgene. This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. Also, it is thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Sun Oct 01 00:00:00 EDT 2023

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Cell biology and toxicology

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Nature

Wang JQ,Li LL,Hu A,Deng G,Wei J,Li YF,Liu YB,Lu XY,Qiu ZP,Shi XJ,Zhao X,Luo J,Song BL

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RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells.

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Ma H,Nie C,Chen Y,Li J,Xie Y,Tang Z,Gao Y,Ai S,Mao Y,Sun Q,Lu R

Tue Sep 07 00:00:00 EDT 2021

ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition.

International journal of biological sciences

Li Y,Sun C,Tan Y,Zhang H,Li Y,Zou H

Mon Jan 03 00:00:00 EST 2022

Characteristics and clinical significance of polyploid giant cancer cells in laryngeal carcinoma.

Laryngoscope investigative otolaryngology

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Fri May 01 00:00:00 EDT 2020

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A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.

Cell cycle (Georgetown, Tex.)

Wang Y,Han T,Gan M,Guo M,Xie C,Jin J,Zhang S,Wang P,Cao J,Wang JB

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Pathology, research and practice

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Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway.

Life sciences

Wang Y,Lv Y,Liu TS,Yan WD,Chen LY,Li ZH,Piao YS,An RB,Lin ZH,Ren XS

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Cell adhesion & migration

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Sun Dec 01 00:00:00 EST 2019

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Molecules (Basel, Switzerland)

Fan Y,Mao Y,Cao S,Xia G,Zhang Q,Zhang H,Qiu F,Kang N

Sat Dec 01 00:00:00 EST 2018

S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells.

Molecules (Basel, Switzerland)

Fan Y,Mao Y,Cao S,Xia G,Zhang Q,Zhang H,Qiu F,Kang N

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Cell death & disease

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Li W,Liu J,Fu W,Zheng X,Ren L,Liu S,Wang J,Ji T,Du G

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Journal of experimental & clinical cancer research : CR

Li W,Liu J,Fu W,Zheng X,Ren L,Liu S,Wang J,Ji T,Du G

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A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

Nature communications

Xu X,Fan Z,Liang C,Li L,Wang L,Liang Y,Wu J,Chang S,Yan Z,Lv Z,Fu J,Liu Y,Jin S,Wang T,Hong T,Dong Y,Ding L,Cheng L,Liu R,Fu S,Jiao S,Ye Q

Tue Jan 17 00:00:00 EST 2017

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

Nature communications

Xu X,Fan Z,Liang C,Li L,Wang L,Liang Y,Wu J,Chang S,Yan Z,Lv Z,Fu J,Liu Y,Jin S,Wang T,Hong T,Dong Y,Ding L,Cheng L,Liu R,Fu S,Jiao S,Ye Q

Tue Jan 17 00:00:00 EST 2017

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

Nature communications

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Oncotarget

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Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.

Oncotarget

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TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.

PloS one

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Bioinformatics

Protein Aliases: Dual specificity phosphatase Cdc25C; EC 3.1.3.48; M-phase inducer phosphatase 3; mitosis inducer CDC25; MPIP3; OTTHUMP00000159490; OTTHUMP00000224012; OTTHUMP00000224013; OTTHUMP00000224016; phosphotyrosine phosphatase; protein phosphatase 1, regulatory subunit 60

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Gene Aliases: CDC25; CDC25C; PPP1R60

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UniProt ID: (Human) P30307

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Entrez Gene ID: (Human) 995

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Function(s)

phosphoprotein phosphatase activity protein tyrosine phosphatase activity protein binding protein kinase binding WW domain binding protein phosphatase

Process(es)

regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle DNA replication DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic nuclear division regulation of mitotic nuclear division spermatogenesis cell proliferation viral process peptidyl-tyrosine dephosphorylation cell division regulation of cell cycle

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDC25C Polyclonal Antibody

CDC25C Antibody (16485-1-AP) in IHC (P)

Product Details

16485-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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