Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (86%), Rat (85%), Rhesus Monkey (99%), Chimpanzee (98%), Bovine (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Cell division cycle-associated 7-like protein (or RAM2) is a transcription factor which plays a role in transcriptional regulation and apoptotic signaling pathways. It acts as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cell division cycle associated 7-like; Cell division cycle-associated 7-like protein; Protein JPO2; Transcription factor RAM2
Gene Aliases: CDCA7L; HR1; JPO2; R1; RAM2
UniProt ID: (Human) Q96GN5
Entrez Gene ID: (Human) 55536