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Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset (100%) Chimpanzee, Monkey (93%).
CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. CDCP1 is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Protein Aliases: CD318; CUB domain-containing protein 1; gp140; Membrane glycoprotein gp140; SIMA135; Subtractive immunization M plus HEp3-associated 135 kDa protein; Transmembrane and associated with src kinases
Gene Aliases: CD318; CDCP1; SIMA135; TRASK; UNQ2486/PRO5773
UniProt ID: (Human) Q9H5V8
Entrez Gene ID: (Human) 64866