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Proteintech
CDK5RAP2 Polyclonal Antibody
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Product Details
31702-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDK5RAP2 fusion protein Ag36245
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MQLFSEIHNL QNKFRDLSPP RYDSLVQSQA RELSLQRQQI KDGHGICVIS RQHMNTMIKA FEELLQASDV DYCVAEGFQE QLNQCAELLE KLEKLFLNGK SVGVEMNTQN ELMERIEEDN LTYQHLLPES PEPSASHALS DYETSEKSFF SRDQKQDNET EKTSVMVNSF SQDLLMEHIQ EIRTLRKRLE ESIKTNEKLR KQLERQGSEF VQGSTSIFAS GSELHSSLTS EIHFLRKQNQ ALNAMLIKGS RDKQKENDKL RESLSRKTVS LEHLQREYAS VKEENERLQK EGSEKERHNQ QLIQEVRCSG QELSRVQEEL KLRQQLLSQN DKLLQSLRVE LKAYEKLDEE H
Target Information
CDK5RAP2 is a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein is localized to the centrosome and Golgi complex and interacts with CDK5R1 and pericentrin (PCNT). CDK5RAP2 plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK5 activator-binding protein C48; CDK5 regulatory subunit-associated protein 2; centrosomal protein 215 kDa; Centrosome-associated protein 215; centrosomin
Gene Aliases: C48; CDK5RAP2; CEP215; KIAA1633; MCPH3
UniProt ID: (Human) Q96SN8
Entrez Gene ID: (Human) 55755
G2/M transition of mitotic cell cycle
establishment of mitotic spindle orientation
microtubule cytoskeleton organization
microtubule bundle formation
chromosome segregation
centriole replication
brain development
neurogenesis
microtubule organizing center organization
regulation of neuron differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
negative regulation of centriole replication
centrosome organization
regulation of spindle checkpoint
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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