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Proteintech
CDK9 Polyclonal Antibody
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Product Details
11705-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDK9 Fusion Protein Ag2318 (1-372 aa encoded by BC001968)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAKQYDSVE CPFCDEVSKY EKLAKIGQGT FGEVFKARHR KTGQKVALKK VLMENEKEGF PITALREIKI LQLLKHENVV NLIEICRTKA SPYNRCKGSI YLVFDFCEHD LAGLLSNVLV KFTLSEIKRV MQMLLNGLYY IHRNKILHRD MKAANVLITR DGVLKLADFG LARAFSLAKN SQPNRYTNRV VTLWYRPPEL LLGERDYGPP IDLWGAGCIM AEMWTRSPIM QGNTEQHQLA LISQLCGSIT PEVWPNVDNY ELYEKLELVK GQKRKVKDRL KAYVRDPYAL DLIDKLLVLD PAQRIDSDDA LNHDFFWSDP MPSDLKGMLS THLTSMFEYL APPRRKGSQI TQQSTNQSRN PATTNQTEFE RVF (1-372 aa encoded by BC001968)
Target Information
CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-2K; CDC2-related kinase; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Cyclin-dependent kinase 9; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit; unnamed protein product
Gene Aliases: C-2k; CDC2L4; CDK9; CTK1; PITALRE; TAK
UniProt ID: (Human) P50750
Entrez Gene ID: (Human) 1025
nucleotide binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription coactivator binding
DNA binding
chromatin binding
obsolete transcription elongation regulator activity
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
transferase activity
snRNA binding
protein kinase binding
7SK snRNA binding
protein serine kinase activity
DNA repair
regulation of DNA repair
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein phosphorylation
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
cell proliferation
replication fork processing
regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
positive regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
regulation of muscle cell differentiation
nucleus localization
regulation of cell cycle
cellular response to cytokine stimulus
negative regulation of protein localization to chromatin
positive regulation of protein localization to chromatin
transcription elongation-coupled chromatin remodeling
transcription pausing by RNA polymerase II
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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