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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: ASEAEAPDK HGSSFVSLLK SSVNSHMTQS TDSRQQSGSP KKSALEGSSA SASQSSSEIE VPLLGSSGSS EVELPLLSSK PSSETASSGL TSKTSSEASV SSSVAKNSSS SGTSLLTPKS SSSTNTSLLT SKSTSQVAAS LLASKSSSQT SGSLVSKSTS LASVSQLASK SSSQTSTSQL PSKSTSQSSE SSVKFSCKLT NEDVKQKQPF FNRLYKTVAW KLVAVGGFSP NVNHGELLNA AIEALKATLD VFFVPLKELA DLPQNKSSQE SIVCELRCKS VYLGTGCGKS KENAKAVASR EALKLFLKKK VVVKICKRKY RGSEIEDLVL LDEESRPVNL PPALKHPQEL L (230-579 aa encoded by BC022270)
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: collaborates/cooperates with ARF (alternate reading frame) protein; collaborator of ARF; unnamed protein product; XRN2 binding domain containing 2
Gene Aliases: 4921511I16Rik; RGD1305302; XTBD2
UniProt ID: (Human) Q9NXV6, (Mouse) Q8BI72, (Rat) Q5U2X0
Entrez Gene ID: (Human) 55602, (Mouse) 70925, (Rat) 306455
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