Immunogen sequence: ASEAEAPDK HGSSFVSLLK SSVNSHMTQS TDSRQQSGSP KKSALEGSSA SASQSSSEIE VPLLGSSGSS EVELPLLSSK PSSETASSGL TSKTSSEASV SSSVAKNSSS SGTSLLTPKS SSSTNTSLLT SKSTSQVAAS LLASKSSSQT SGSLVSKSTS LASVSQLASK SSSQTSTSQL PSKSTSQSSE SSVKFSCKLT NEDVKQKQPF FNRLYKTVAW KLVAVGGFSP NVNHGELLNA AIEALKATLD VFFVPLKELA DLPQNKSSQE SIVCELRCKS VYLGTGCGKS KENAKAVASR EALKLFLKKK VVVKICKRKY RGSEIEDLVL LDEESRPVNL PPALKHPQEL L (230-579 aa encoded by BC022270)
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDKN2A-interacting protein; collaborates/cooperates with ARF (alternate reading frame) protein; Collaborator of ARF
Gene Aliases: 4921511I16Rik; AW208986; CARF; CDKN2AIP; RGD1305302
Molecular Function: DNA-binding transcription factor