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CDT2 Polyclonal Antibody
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Product Details
BS-7935R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RAMP/CDT2, amino acids 181-280.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: contains WD-40 repeats; DDB1- and CUL4-associated factor 2; denticleless E3 ubiquitin protein ligase homolog (Drosophila); denticleless homolog; Denticleless protein homolog; L2DTL; CDT2; Lethal(2) denticleless protein homolog; Meth A RAMP; Meth A retinoic acid-regulated nuclear matrix-associated protein; RA-regulated nuclear matrix-associated protein; RAMP; Retinoic acid-regulated nuclear matrix-associated protein; unnamed protein product
Gene Aliases: 2810047L02Rik; 5730564G15Rik; CDT2; CDW1; DCAF2; DTL; L2DTL; RAMP; RGD1310439
UniProt ID: (Human) Q9NZJ0, (Mouse) Q3TLR7
Entrez Gene ID: (Human) 51514, (Mouse) 76843, (Rat) 305073
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
response to UV
translesion synthesis
regulation of cell cycle
DNA replication
mitotic G2 DNA damage checkpoint
positive regulation of catabolic process
positive regulation of G2/M transition of mitotic cell cycle
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
rhythmic process
positive regulation of protein metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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