PA5-29652 targets CDX2 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29652 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 241 of Human CDX2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al., 1994 [PubMed 7698771]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: caudal type homeo box transcription factor 2; caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX-3; CDX3; Homeobox protein CDX-2; homeobox protein miniCDX2
Gene Aliases: CDX-3; CDX2; CDX2/AS; CDX3
UniProt ID: (Human) Q99626
Entrez Gene ID: (Human) 1045