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Product Details
PA5-120683
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human BMPR1B (NP_001194.1).
Conjugate
Form
Liquid
Concentration
3.49 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914255
Product Specific Information
Positive test controls include: 293T, HeLa, SH-SY5Y. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein.
Immunogen sequence: MLLRSAGKLN VGTKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHR
Target Information
BMPR1B (also known as ALK6, CDw293) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. BMPR1B is mainly involved in the endochondral bone formation and embryogenesis. BMPR1B expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients. BMPR1B receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activin receptor-like kinase 6; ALK-6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein binding serine/threonine kinase receptor; bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase; Serine/threonine-protein kinase receptor R6; SKR6
Gene Aliases: Acvrlk6; AI385617; ALK-6; ALK6; AMDD; AV355320; BDA1D; BDA2; BMPR-1B; BMPR-IB; BMPR1B; CDw293; CFK-43a; SKR6
UniProt ID: (Human) O00238, (Mouse) P36898
Entrez Gene ID: (Human) 658, (Mouse) 12167, (Rat) 310914
glycoprotein binding
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
SMAD binding
metal ion binding
nucleotide binding
protein kinase activity
transforming growth factor beta-activated receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
serine/threonine protein kinase receptor
skeletal system development
cartilage condensation
ovarian cumulus expansion
eye development
chondrocyte development
protein phosphorylation
inflammatory response
dorsal/ventral pattern formation
signal transduction by protein phosphorylation
proteoglycan biosynthetic process
positive regulation of bone mineralization
BMP signaling pathway
retinal ganglion cell axon guidance
positive regulation of chondrocyte differentiation
limb morphogenesis
ovulation cycle
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
retina development in camera-type eye
endochondral bone morphogenesis
positive regulation of cartilage development
cellular response to BMP stimulus
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of chondrocyte proliferation
chondrocyte differentiation
estrogen biosynthetic process
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
phosphorylation
cell differentiation
camera-type eye development
cartilage development
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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