The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adhesion G protein-coupled receptor C2; cadherin EGF LAG seven-pas G-type receptor 2; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); EGF-like protein 2; EGF-like-domain, multiple 2; epidermal growth factor-like 2; Epidermal growth factor-like protein 2; Flamingo homolog; Flamingo homolog 3; flamingo-like protein celsr2; Flamingo1; FLJ34118; FLJ42737; FLJ45143; FLJ45845; Multiple EGF-like domains protein 3; multiple epidermal growth factor-like domains 3; Multiple epidermal growth factor-like domains protein 3; seven-pass transmembrane cadherin
Gene Aliases: ADGRC2; CDHF10; CELSR2; EGFL2; flamingo; Flamingo1; KIAA0279; MEGF3; mfmi1; mKIAA0279