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Invitrogen
CELSR2 Polyclonal Antibody
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Product Details
PA5-33423
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from C-terminus of human CELSR2 / EGFL2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Hamster, Elephant, Panda, Horse, Rabbit (100%) Opossum (94%).
Target Information
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion G protein-coupled receptor C2; cadherin EGF LAG seven-pas G-type receptor 2; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; cadherin, EGF LAG seven-pass G-type receptor 2; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); EGF-like protein 2; EGF-like-domain, multiple 2; epidermal growth factor-like 2; Epidermal growth factor-like protein 2; Flamingo homolog; Flamingo homolog 3; flamingo-like protein celsr2; Flamingo1; FLJ34118; FLJ42737; FLJ45143; FLJ45845; multiple EGF like domains 3; Multiple EGF-like domains protein 3; multiple epidermal growth factor-like domains 3; Multiple epidermal growth factor-like domains protein 3; seven-pass transmembrane cadherin; unnamed protein product
Gene Aliases: ADGRC2; CDHF10; CELSR2; EGFL2; flamingo; Flamingo1; I79_019398; KIAA0279; MEGF3; mfmi1; mKIAA0279
UniProt ID: (Human) Q9HCU4, (Mouse) Q9R0M0
cilium movement
regulation of transcription, DNA-templated
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
nervous system development
axonogenesis
anterior/posterior pattern specification
Wnt signaling pathway
ventricular system development
neural plate anterior/posterior regionalization
regulation of cell-cell adhesion
regulation of protein localization
cerebrospinal fluid secretion
cell-cell adhesion mediated by cadherin
animal organ development
dendrite morphogenesis
Wnt signaling pathway, planar cell polarity pathway
cilium morphogenesis
motor neuron migration
plasma membrane bounded cell projection organization
neuron migration
multicellular organism development
cilium assembly
spermatogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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