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Search Thermo Fisher Scientific
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
CEP164 was initially identified as a centrosomal protein, but other studies have indicated that it also plays a role in the formation of primary cilia, the microtubule-based sensory antennae projecting from the surface of many eukaryotic cells as well as in DNA damage response acting as a mediator protein. CEP164 interacts with both ATR and ATM, proteins that trigger a number of cellular responses including the initiation of DNA damaged-induced cell cycle checkpoints. It is phosphorylated upon replication stress, ultraviolet (UV) radiation, and ionizing radiation silencing of CEP164 significantly reduces the DNA damage-induced phosphorylation of several proteins in the DNA damage-activated signaling cascade and compromises cell survival after UV damage. At least two isoforms of CEP164 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ce164; centrosomal protein 164; centrosomal protein 164kDa; Centrosomal protein of 164 kDa; Cep 164; Cep164
Gene Aliases: AI450905; BC027092; CEP164; D030051D21; KIAA1052; mKIAA1052; NPHP15; RGD1560988; RGD1561243
UniProt ID: (Human) Q9UPV0
Entrez Gene ID: (Human) 22897, (Mouse) 214552, (Rat) 363055
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