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Proteintech
CFLAR/FLIP Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-10394
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CFLAR/FLIP fusion protein Ag0593
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: DVVPPNVRD LLDILRERGK LSVGDLAELL YRVRRFDLLK RILKMDRKAV ETHLLRNPHL VSDYRVLMAE IGEDLDKSDV SSLIFLMKDY MGRGKISKEK SFLDLVVELE KLNLVAPDQL DLLEKCLKNI HRIDLKTKIQ KYKQSVQGAG TSYRN
Target Information
FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-FLIP; CASH; CASP8 and FADD-like apoptosis regulator; Caspase homolog; Caspase-eight-related protein; Caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory protein; CLARP; FADD-like antiapoptotic molecule 1; FLAME-1; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; testis secretory sperm-binding protein Li 233m; Usurpin; usurpin beta
Gene Aliases: 2310024N18Rik; A430105C05Rik; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CFLAR; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; FLAME1; FLIP; Gm9845; I-FLICE; MRIT
UniProt ID: (Human) O15519, (Mouse) O35732
Entrez Gene ID: (Human) 8837, (Mouse) 12633
protease binding
death receptor binding
protein binding
enzyme activator activity
protein complex binding
cysteine-type endopeptidase activity involved in execution phase of apoptosis
peptidase activator activity
death effector domain binding
protein heterodimerization activity
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
protease
proteolysis
apoptotic process
skeletal muscle tissue development
skeletal muscle atrophy
regulation of skeletal muscle satellite cell proliferation
skeletal myofibril assembly
viral process
negative regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
skeletal muscle tissue regeneration
positive regulation of NF-kappaB transcription factor activity
regulation of necroptotic process
execution phase of apoptosis
negative regulation of myoblast fusion
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of peptidase activity
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of necroptotic process
apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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