This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: TAVTMGKVTK SMAGVVKSMD ATLKTMNLEK ISALMDKFEH QFETLDVQTQ QMEDTMSSTT
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C10orf2; C18-ORF2; C18orf2; Charged multivesicular body protein 1B; CHMP1.5; CHMP1b; chromatin modifying protein 1B; Chromatin-modifying protein 1b; hVps46-2; vacuolar protein sorting 46-2; Vacuolar protein sorting-associated protein 46-2; Vps46-2; Vps46B
Gene Aliases: C10orf2; C18-ORF2; C18orf2; CHMP1.5; CHMP1B; hVps46-2; Vps46-2; Vps46B
UniProt ID: (Human) Q7LBR1
Entrez Gene ID: (Human) 57132
Molecular Function: membrane traffic protein