Recommended positive controls: HeLa, HeLa cytoplasm, mouse kidney.
Predicted reactivity: Mouse (90%), Rat (91%), Pig (95%), Chicken (82%), Rhesus Monkey (99%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Charged multivesicular body protein 4c; CHMP4c; chromatin modifying protein 4C; Chromatin-modifying protein 4c; hSnf7-3; hVps32-3; Shax3; SNF7 homolog associated with Alix 3; Snf7 homologue associated with Alix 3; SNF7-3; Vacuolar protein sorting-associated protein 32-3; Vps32-3; VPS32C
Gene Aliases: 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; CHMP4C; SHAX3; SNF7-3; VPS32C
Molecular Function: transfer/carrier protein