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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 168 of Human CHMP4C|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-32050 targets CHMP4C in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-32050 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 168 of Human CHMP4C.
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
charged multivesicular body protein 4c; chromatin modifying protein 4C; chromatin-modifying protein 4c; hSnf7-3; hVps32-3; Shax3; SNF7 homolog associated with Alix 3; Snf7 homologue associated with Alix 3; vacuolar protein sorting-associated protein 32-3; vps32-3; VPS32C
2010012P02Rik; 2210015K02Rik; 2310010I16Rik; CHMP4C; SHAX3; SNF7-3; VPS32C