Recommended positive controls: 293T, A431, Jurkat, Raji.
Predicted reactivity: Mouse (95%), Rat (96%), Chicken (81%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CHMP6 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 ).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Charged multivesicular body protein 6; chromatin modifying protein 6; Chromatin-modifying protein 6; hVps20; Vacuolar protein sorting-associated protein 20; Vps20
Gene Aliases: CHMP6; VPS20
UniProt ID: (Human) Q96FZ7
Entrez Gene ID: (Human) 79643
Molecular Function: membrane traffic protein