|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 201 of Human CHMP6|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30815 targets CHMP6 in WB applications and shows reactivity with Human samples.
The PA5-30815 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 201 of Human CHMP6.
CHMP6 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Charged multivesicular body protein 6; chromatin modifying protein 6; Chromatin-modifying protein 6; hVps20; Vacuolar protein sorting-associated protein 20; VPS20
Gene Aliases: CHMP6; VPS20
UniProt ID: (Human) Q96FZ7
Entrez Gene ID: (Human) 79643
Molecular Function: transfer/carrier protein
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