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Proteintech
CHRNA1 Polyclonal Antibody
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Product Details
10613-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHRNA1 Fusion Protein Ag0933 (1-269 aa encoded by BC006314)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEPWPLLLL FSLCSAGLVL GSEHETRLVA KLFKDYSSVV RPVEDHRQVV EVTVGLQLIQ LINVDEVNQI VTTNVRLKQQ WVDYNLKWNP DDYGGVKKIH IPSEKIWRPD LVLYNNADGD FAIVKFTKVL LQYTGHITWT PPAIFKSYCE IIVTHFPFDE QNCSMKLGTW TYDGSVVAIN PESDQPDLSN FMESGEWVIK ESRGWKHSVT YSCCPDTPYL DITYHFVMQR LPLYFIVNVI IPCLLFSFLT GLVFYLPTDS GGCGCHDCCC (1-269 aa encoded by BC006314)
Target Information
Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine.The nAChRs fall into two subclasses, the muscle-type and the neuronal-type. The muscle-type receptor is a pentameric glycoprotein of five membrane spanning subunits, (2 alpha 1's, beta 1, gamma or epsilon and delta) which form a ligand gated ion channel. The neuronal nAChR is also a pentamer, but unlike the muscle-type, is made up of only two general types of subunits, alpha and beta of which multiple subtypes have been described (alpha 2 to alpha 8 and beta 2 to beta 4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acetylcholine receptor; Acetylcholine receptor subunit alpha; acetylcholine receptor, nicotinic, alpha 1 (muscle); cholinergic receptor; cholinergic receptor nicotinic alpha polypeptide 1; cholinergic receptor, nicotinic alpha 1; cholinergic receptor, nicotinic, alpha 1 (muscle); cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle); muscle nicotinic acetylcholine receptor; nAChR; nicotinic acetylcholine receptor alpha subunit; nicotinic acetylcholine receptor alpha subunit|AChR alpha subunit; nicotinic cholinergic receptor alpha 1; unnamed protein product
Gene Aliases: Achr-1; ACHRA; ACHRD; Acra; AI385656; AI608266; CHNRA; CHRNA; CHRNA1; CMS1A; CMS1B; CMS2A; FCCMS; SCCMS
UniProt ID: (Human) P02708, (Mouse) P04756, (Rat) P25108
Entrez Gene ID: (Human) 1134, (Mouse) 11435, (Rat) 79557
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
acetylcholine receptor activity
acetylcholine-gated cation channel activity
acetylcholine binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
acetylcholine-activated cation-selective channel activity
protein binding
ligand-gated ion channel
skeletal muscle contraction
ion transport
cation transport
synaptic transmission, cholinergic
neuromuscular synaptic transmission
neuromuscular junction development
neuronal action potential
ion transmembrane transport
response to nicotine
regulation of membrane potential
muscle cell cellular homeostasis
skeletal muscle tissue growth
musculoskeletal movement
neuromuscular process
membrane depolarization
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
neuron cellular homeostasis
acetylcholine receptor signaling pathway
presynaptic modulation of chemical synaptic transmission
transport
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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