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CHRNA1 Polyclonal Antibody

CHRNA1 Antibody in Immunocytochemistry (ICC/IF)

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CHRNA1 Antibody (10613-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed C2C12 cell using 10613-1-AP (CHRNA1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CHRNA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

10613-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHRNA1 Fusion Protein Ag0933 (1-269 aa encoded by BC006314)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEPWPLLLL FSLCSAGLVL GSEHETRLVA KLFKDYSSVV RPVEDHRQVV EVTVGLQLIQ LINVDEVNQI VTTNVRLKQQ WVDYNLKWNP DDYGGVKKIH IPSEKIWRPD LVLYNNADGD FAIVKFTKVL LQYTGHITWT PPAIFKSYCE IIVTHFPFDE QNCSMKLGTW TYDGSVVAIN PESDQPDLSN FMESGEWVIK ESRGWKHSVT YSCCPDTPYL DITYHFVMQR LPLYFIVNVI IPCLLFSFLT GLVFYLPTDS GGCGCHDCCC (1-269 aa encoded by BC006314)

Target Information

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine.The nAChRs fall into two subclasses, the muscle-type and the neuronal-type. The muscle-type receptor is a pentameric glycoprotein of five membrane spanning subunits, (2 alpha 1's, beta 1, gamma or epsilon and delta) which form a ligand gated ion channel. The neuronal nAChR is also a pentamer, but unlike the muscle-type, is made up of only two general types of subunits, alpha and beta of which multiple subtypes have been described (alpha 2 to alpha 8 and beta 2 to beta 4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MiR-142a-3p: A novel ACh receptor transcriptional regulator in association with peripheral nerve injury.

Molecular therapy. Nucleic acids

Qi Z,Wang S,Xuan A,Gu X,Deng J,Huang C,Zhang L,Yin X

Tue Dec 13 00:00:00 UTC 2022

Self-curling 3D oriented scaffolds from fish scales for skeletal muscle regeneration.

Biomaterials research

Shi Y,Zhang X,Liu R,Shao X,Zhao Y,Gu Z,Jiang Q

Thu Dec 22 00:00:00 UTC 2022

Widespread Mislocalization of FUS Is Associated With Mitochondrial Abnormalities in Skeletal Muscle in Amyotrophic Lateral Sclerosis With FUS Mutations.

Journal of neuropathology and experimental neurology

Yu M,Zhao X,Wu W,Wang Q,Liu J,Zhang W,Yuan Y,Hong D,Wang Z,Deng J

Thu Feb 24 00:00:00 UTC 2022

Association of a newly identified lncRNA LNC_000280 with the formation of acetylcholine receptor clusters in vitro.

Biochemical and biophysical research communications

Deng J,Wang S,Meng S,Qi Z,Gu X,Huang C,Yin X

Sat Jun 25 00:00:00 UTC 2022

Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses.

Frontiers in pharmacology

Xu T,Yang D,Liu K,Gao Q,Liu Z,Li G

Sat Jul 16 00:00:00 UTC 2022

A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.

Aging

Wu X,Sheng H,Wang L,Xia P,Wang Y,Yu L,Lv W,Hu J

Fri Mar 26 00:00:00 UTC 2021

A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota.

Translational psychiatry

Guo Y,Zhu X,Zeng M,Qi L,Tang X,Wang D,Zhang M,Xie Y,Li H,Yang X,Chen D

Thu May 27 00:00:00 UTC 2021

Maternal high sugar and fat diet benefits offspring brain function via targeting on the gut-brain axis.

Aging

Wang D,Zhang H,Zeng M,Tang X,Zhu X,Guo Y,Qi L,Xie Y,Zhang M,Chen D

Fri Mar 26 00:00:00 UTC 2021

An improved method for culturing myotubes on laminins for the robust clustering of postsynaptic machinery.

Scientific reports

Pęziński M,Daszczuk P,Pradhan BS,Lochmüller H,Prószyński TJ

Wed Mar 11 00:00:00 UTC 2020

Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery.

Scientific reports

Bernadzki KM,Gawor M,Pęziński M,Mazurek P,Niewiadomski P,Rędowicz MJ,Prószyński TJ

Tue Aug 22 00:00:00 UTC 2017

Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery.

Scientific reports

Bernadzki KM,Gawor M,Pęziński M,Mazurek P,Niewiadomski P,Rędowicz MJ,Prószyński TJ

Tue Aug 22 00:00:00 UTC 2017

Transcriptional profiling of rat skeletal muscle hypertrophy under restriction of blood flow.

Gene

Xu S,Liu X,Chen Z,Li G,Chen Q,Zhou G,Ma R,Yao X,Huang X

Thu Dec 15 00:00:00 UTC 2016

Transcriptional profiling of rat skeletal muscle hypertrophy under restriction of blood flow.

Gene

Xu S,Liu X,Chen Z,Li G,Chen Q,Zhou G,Ma R,Yao X,Huang X

Thu Dec 15 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: acetylcholine receptor; Acetylcholine receptor subunit alpha; acetylcholine receptor, nicotinic, alpha 1 (muscle); cholinergic receptor; cholinergic receptor nicotinic alpha polypeptide 1; cholinergic receptor, nicotinic alpha 1; cholinergic receptor, nicotinic, alpha 1 (muscle); cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle); muscle nicotinic acetylcholine receptor; nAChR; nicotinic acetylcholine receptor alpha subunit; nicotinic cholinergic receptor alpha 1

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Gene Aliases: Achr-1; ACHRA; ACHRD; Acra; AI385656; AI608266; CHNRA; CHRNA; CHRNA1; CMS1A; CMS1B; CMS2A; FCCMS; SCCMS

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UniProt ID: (Human) P02708, (Mouse) P04756, (Rat) P25108

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Entrez Gene ID: (Human) 1134, (Mouse) 11435, (Rat) 79557

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Function(s)

acetylcholine-activated cation-selective channel activity ion channel activity ligand-gated ion channel activity acetylcholine receptor activity acetylcholine binding extracellular ligand-gated ion channel activity protein binding ligand-gated ion channel

Process(es)

skeletal muscle contraction transport signal transduction synaptic transmission, cholinergic neuromuscular synaptic transmission neuromuscular junction development neuronal action potential response to nicotine regulation of membrane potential muscle cell cellular homeostasis skeletal muscle tissue growth musculoskeletal movement neuromuscular process neuron cellular homeostasis cation transmembrane transport ion transport cation transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CHRNA1 Polyclonal Antibody

CHRNA1 Antibody (10613-1-AP) in ICC/IF

Product Details

10613-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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