Proteintech

CHRNB4 Polyclonal Antibody

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Antibody Testing Data (4)

FIGURE: 1 / 4

CHRNB4 Antibody (22192-1-AP) in WB

Mouse testis tissue were subjected to SDS PAGE followed by western blot with 22192-1-AP (CHRNB4 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

Product Image Gallery

CHRNB4 Antibody in Flow Cytometry (Flow) — 1X10^6 SH-SY5Y cells were stained with 0.2ug CHRNB4 antibody (22192-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1500.

Product Details

22192-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 3 publications 3 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHRNB4 Fusion Protein Ag16767 (332-451 aa encoded by BC096080)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: WVKRCFLHK LPTFLFMKRP GPDSSPARAF PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP AGSTPVAIPR DFWLRSSGRF RQDVQEALEG VSFIAQHMKN DDEDQSVVED W (332-451 aa encoded by BC096080)

Target Information

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer.

Cancers

Chuang YH,Lee CH,Lin CY,Liu CL,Huang SH,Lee JY,Chiu YY,Lee JC,Yang JM

Fri May 22 00:00:00 EDT 2020

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA.

Marine drugs

Sun Z,Zhangsun M,Dong S,Liu Y,Qian J,Zhangsun D,Luo S

Fri Jan 17 00:00:00 EST 2020

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets.

Marine drugs

Liu Y,Qian J,Sun Z,Zhangsun D,Luo S

Sun Apr 28 00:00:00 EDT 2019

Identification of nicotinic acetylcholine receptor subunits in different lung cancer cell lines and the inhibitory effect of alpha-conotoxin TxID on lung cancer cell growth.

European journal of pharmacology

Qian J,Liu YQ,Sun ZH,Zhangsun DT,Luo SL

Sun Dec 15 00:00:00 EST 2019

Bioinformatics

Protein Aliases: acetylcholine receptor; acetylcholine receptor, nicotinic, beta 4 (neuronal); cholinergic receptor; cholinergic receptor, nicotinic beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; nAChRB4; Neuronal acetylcholine receptor subunit beta-4; neuronal nicotinic receptor beta 4 subunit; nicotinic acetylcholine receptor beta4 subunit

Gene Aliases: Acrb-4; Acrb4; CHRNB4

UniProt ID: (Human) P30926, (Mouse) Q8R493

Entrez Gene ID: (Human) 1143, (Mouse) 108015

Molecular Function: ligand-gated ion channel