Immunogen sequence: PMWHLWQALY PGDAESLQGA LRDMLRSLFR CDFSVLRLYA PPGDPAARAP DTANLTTAAL FRWRTNKVIC SPPLCPGAPR ARAEVGLVED TACERSCPPV AIRALEAECR KYPVVVIKDV RLLDLGVLVP LLRDPGLNLK VVQL
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
This gene belongs to the sulfotransferase gene family. Sulfotransferases generate sulfated glycosaminoglycan (GAG) moities during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by transferring sulfate with remarkable specificity for the underlying oligosaccharide substrate. This gene product mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of this gene family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as regulators of many biologic processes. This gene is part of a gene cluster on chromosome Xp11.23.
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Protein Aliases: C6ST-2; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7; Carbohydrate sulfotransferase 7; Chondroitin 6-sulfotransferase 2; chondroitin 6-sulfotransferase-2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; GlcNAc6ST-4; gn6st-4; GST-5; N-acetylglucosamine 6-O-sulfotransferase 4
Gene Aliases: C6ST-2; CHST7; GST-5
UniProt ID: (Human) Q9NS84
Entrez Gene ID: (Human) 56548