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Invitrogen
CHX10 Polyclonal Antibody
Product Details
PA1-12565
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Protein corresponding to residues 264-361 from the C terminus of human Chx10, conjugated to KLH.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2216011
Product Specific Information
By Western blot, this antibody detects a ~46 kDa band. A suggested positive control for this product is rat or mouse retinal tissue lysate.
Target Information
CHX10 encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C. elegans ceh-10 homeo domain containing homolog; ceh-10 homeo domain containing homolog; ceh-10 homeodomain containing homolog; Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10; ocular retardation; Visual system homeobox 2
Gene Aliases: CHX10; Hox-10; HOX10; MCOP2; MCOPCB3; or; RET1; VSX2
UniProt ID: (Human) A1A4X6, (Chicken) Q9IAL1, (Mouse) Q61412
Entrez Gene ID: (Human) 338917, (Chicken) 395536, (Mouse) 12677, (Rat) 171360
sequence-specific DNA binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
chromatin binding
DNA binding
protein binding
helix-turn-helix transcription factor
homeodomain transcription factor
DNA-binding transcription factor
gene-specific transcriptional regulator
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
visual perception
response to stimulus
regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
camera-type eye development
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
retinal bipolar neuron differentiation
retina morphogenesis in camera-type eye
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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