In Western blot applications, this antibody detects a band at ~23kDa. A suggested positive control is human brain tissue lysate.
PA5-19907 can be used with blocking peptide PEP-0033.
Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues.
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Protein Aliases: Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A; CIDE-A
Gene Aliases: CIDE-A; CIDEA
UniProt ID: (Human) O60543
Entrez Gene ID: (Human) 1149