In Western blot applications, this antibody detects a band at ~25kDa. A suggested positive control is mouse heart tissue lysate.
PA5-19908 can be used with blocking peptide PEP-0034.
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-A is expressed in many tissues.
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Protein Aliases: Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A; CIDE-A
Gene Aliases: AW212747; Cidea
UniProt ID: (Mouse) O70302
Entrez Gene ID: (Mouse) 12683