Suggested positive control: antigen standard for CIDEC (transient overexpression lysate).
DNA fragmentation is one of the critical steps in apoptosis, which is induced by DNA fragmentation factor (DFF). DFF is composed of two subunits, a 40 kDa caspase-activated nuclease (DFF40) and a 45 kDa inhibitor (DFF45). Recently a novel family of cell-death-inducing DFF45-like effectors (CIDEs) has been identified. Human CIDE-3 is a novel member of CIDEs. There are 2 transcripts, CIDE-3 and CIDE-3alpha, were present in HepG2 and A375 cells. Consistent with its chromosome localization at 3p25, a region associated with high frequency loss of heterozygosity in many tumours, CIDE-3 may play an important role in prevention of tumorigenesis.
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Protein Aliases: Cell death activator CIDE-3; cell death-inducing DFFA-like effector c; Cell death-inducing DFFA-like effector protein C; CID; CIDE-3alpha; fat specific gene 27; fat specific protein 27; Fat-specific protein FSP27; Fat-specific protein FSP27 homolog
Gene Aliases: CIDE-3; CIDE3; CIDEC; FPLD5; FSP27