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Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
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Protein Aliases: Cartilage intermediate layer protein 1; Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; cartilage intermediate layer protein, nucleotide pyrophosphohydrolase; Cartilage intermediate-layer protein; CILP-1; HGNC:1980
Gene Aliases: 9830114D16; C130036G17Rik; CILP; CILP-1; HsT18872; UNQ602/PRO1188
UniProt ID: (Human) O75339, (Mouse) Q66K08
Entrez Gene ID: (Human) 8483, (Mouse) 214425, (Rat) 315761
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