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CILP Polyclonal Antibody

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CILP Antibody in Western Blot (WB) — MCF-7 lysate probed with Rabbit Anti-CILP Polyclonal Antibody, Unconjugated (bs-13954R) at 1:300 in 4°C overnight. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37°C.

Product Details

BS-13954R

Applications	Tested Dilution	Publications
Western Blot (WB)	1:300	-
Immunohistochemistry (Paraffin) (IHC (P))	1:200-1:400	-
Immunohistochemistry (Frozen) (IHC (F))	1:100-1:500	-
Immunocytochemistry (ICC/IF)	1:100-1:500	-
Flow Cytometry (Flow)	1:20-1:100	-
ELISA (ELISA)	1:500-1:1,000	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KLH conjugated synthetic peptide derived from human CILP, amino acids 1051-1184. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A
Storage buffer	PBS with 50% glycerol, 1% BSA
Contains	0.09% sodium azide
Storage conditions	-20°C

Target Information

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cartilage intermediate layer protein 1; Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; cartilage intermediate layer protein, nucleotide pyrophosphohydrolase; Cartilage intermediate-layer protein; CILP-1; HGNC:1980

Gene Aliases: 9830114D16; C130036G17Rik; CILP; CILP-1; HsT18872; UNQ602/PRO1188

UniProt ID: (Human) O75339, (Mouse) Q66K08

Entrez Gene ID: (Human) 8483, (Mouse) 214425, (Rat) 315761

Function(s)

negative regulation of insulin-like growth factor receptor signaling pathway biological_process

Process(es)

alkaline phosphatase activity nucleotide diphosphatase activity molecular_function carbohydrate binding