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Bethyl Laboratories
CKI epsilon Polyclonal Antibody
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FIGURE: 1 / 2
CKI epsilon Antibody (A302-135A) in WB
Detection of human CKI epsilon by western blot. Samples: Whole cell lysate (5, 15, and 50 µg) from HeLa cells. Antibody: Affinity purified rabbit anti-CKI epsilon antibody (Product # A302-135A) (lot A302-135A-1) used at 0.04 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A302-135A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 366 and 416 of human casein kinase 1, epsilon.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse and Chicken
Target Information
CSNK1E (CK1 epsilon) is a serine/threonine kinase implicated in a wide range of cellular functions, including vesicular trafficking, DNA damage repair, cell cycle progression, and cytokinesis. CSNK1E phosphorylate key regulatory proteins involved in the control of cell differentiation, proliferation, chromosome segregation, circadian rhythms, and metabolic pathways. CK1 family members share a highly conserved kinase domain but differ in their variable N-and C-terminal domains. Mammals have seven family members: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CKIe positively regulates Akt possibly by inhibiting PP2A. CKIe play an important role in neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 1; Casein kinase I isoform epsilon; CK1e; CKI-epsilon; CSNK1E; MGC10398; OTTHUMP00000063258; OTTHUMP00000063263; RP1-5O6.1
Gene Aliases: CKIe; CKIepsilon; CSNK1E; HCKIE
UniProt ID: (Human) P49674
Entrez Gene ID: (Human) 1454
DNA repair
protein phosphorylation
endocytosis
signal transduction
protein localization
regulation of Wnt signaling pathway
positive regulation of Wnt signaling pathway
negative regulation of Wnt signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization
circadian regulation of gene expression
non-canonical Wnt signaling pathway
regulation of circadian rhythm
rhythmic process
circadian behavior
negative regulation of small GTPase mediated signal transduction
canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of beta-amyloid formation
cellular response to nerve growth factor stimulus
positive regulation of non-canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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