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Proteintech
FRS2 Monoclonal Antibody (4E10H12), CoraLite® Plus 488
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Product Details
CL488-66263
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG3
Class
Monoclonal
Type
Antibody
Clone
4E10H12
Immunogen
Recombinant Protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Target Information
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; SNT-1; SNT2; Suc1-associated neurotrophic factor target 1; unnamed protein product
Gene Aliases: FRS1A; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
UniProt ID: (Human) Q8WU20
Entrez Gene ID: (Human) 10818
gastrulation with mouth forming second
organ induction
lens development in camera-type eye
ventricular septum development
transmembrane receptor protein tyrosine kinase signaling pathway
transmembrane receptor protein tyrosine phosphatase signaling pathway
G-protein coupled receptor signaling pathway
neuroblast proliferation
fibroblast growth factor receptor signaling pathway
anterior/posterior axis specification, embryo
forebrain development
regulation of apoptotic process
positive regulation of MAPK cascade
optic placode formation involved in camera-type eye formation
regulation of epithelial cell proliferation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
lens fiber cell development
regulation of ERK1 and ERK2 cascade
negative regulation of cardiac muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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