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Proteintech
GART Monoclonal Antibody (2A11E2), CoraLite® Plus 488
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Product Details
CL488-67939
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2A11E2
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAARVLIIGS GGREHTLAWK LAQSHHVKQV LVAPGNAGTA CSEKISNTAI SISDHTALAQ FCKEKKIEFV VVGPEAPLAA GIVGNLRSAG VQCFGPTAEA AQLESSKRFA KEFMDRHGIP TAQWKAFTKP EEACSFILSA DFPALVVKAS GLAAGKGVIV AKSKEEACKA VQEIMQEKAF GAAGETIVIE ELLDGEEVSC LCFTDGKTVA PMPPAQDHKR LLEGDGGPNT GGMGAYCPAP QVSNDLLLKI KDTVLQRTVD GMQQEGTPYT GILYAGIMLT KNGPKVLEFN CRFGDPECQV ILPLLKSDLY EVIQSTLD
Target Information
MERTK is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GAR transformylase; GARS-AIRS-GART; glycinamide ribonucleotide formyltransferase; glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase; MGC47764; phosphoribosylglycinamide formyltransferase; Trifunctional purine biosynthetic protein adenosine-3; unnamed protein product
Gene Aliases: AIRS; Gaps; GARS; GART; GARTF; PAIS; PGFT; PRGS
UniProt ID: (Human) P22102, (Mouse) Q64737
Entrez Gene ID: (Human) 2618, (Mouse) 14450, (Rat) 288259
nucleotide binding
catalytic activity
phosphoribosylamine-glycine ligase activity
phosphoribosylformylglycinamidine cyclo-ligase activity
phosphoribosylglycinamide formyltransferase activity
ATP binding
transferase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
metal ion binding
methyltransferase activity
hydroxymethyl-, formyl- and related transferase activity
ligase
brainstem development
purine nucleotide biosynthetic process
GMP biosynthetic process
'de novo' IMP biosynthetic process
purine nucleobase biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
cerebellum development
cerebral cortex development
'de novo' AMP biosynthetic process
adenine biosynthetic process
'de novo' XMP biosynthetic process
glycine metabolic process
metabolic process
biosynthetic process
ribonucleoside monophosphate biosynthetic process
response to organic substance
response to inorganic substance
tetrahydrofolate biosynthetic process
cobalamin metabolic process
methylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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