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BNIP3 Monoclonal Antibody (2H7D8), CoraLite® Plus 488

View all (21) BNIP3 antibodies

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Product Details

CL488-68091

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2H7D8

Immunogen

BNIP3 fusion protein Ag27935

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MQEESLQGS WVELHFSNNG NGGSVPASVS IYNGDMEKIL LDAQHESGRS SSKSSHCDSP PRSQTPQDTN RASETDTHSI GEKNSSQSEE DDIERRKEVE SILKKNSDWI WDWSSRPENI PPKEFLFKHP KRTATLSMRN TSVMKKGGIF SAEFLKVFLP SLLLSHLLAI GLGIYIGRRL TTSTSTF

Target Information

NIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. NIP3 contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein is known to induce apoptosis, even in the presence of BCL2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B interacting protein 3; BNIP3; Hypoxia-Activated BNIP3 Overlapping Non-coding RNA; lacks exon 2; BNIP3deltaExon2; nineteen kD interacting protein-3; pro-apoptotic mitochondrial protein; unnamed protein product

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Gene Aliases: BNIP3; HABON; NIP3

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UniProt ID: (Human) Q12983

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Entrez Gene ID: (Human) 664

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Function(s)
protein binding identical protein binding protein homodimerization activity GTPase binding endoplasmic reticulum-autophagosome adaptor activity mitochondrion autophagosome adaptor activity
Process(es)
mitophagy mitophagy response to hypoxia apoptotic process response to bacterium positive regulation of autophagy negative regulation of mitochondrial fusion cardiac muscle cell apoptotic process positive regulation of cardiac muscle cell apoptotic process negative regulation of mitochondrial membrane potential positive regulation of macroautophagy cerebral cortex development mitochondrial protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of programmed cell death positive regulation of protein complex disassembly mitochondrial fragmentation involved in apoptotic process negative regulation of membrane potential regulation of mitochondrial membrane permeability autophagic cell death response to axon injury oligodendrocyte differentiation brown fat cell differentiation neuron apoptotic process positive regulation of mitochondrial calcium ion concentration defense response to virus response to hyperoxia reticulophagy substrate localization to autophagosome cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to cobalt ion cellular response to hypoxia reactive oxygen species metabolic process positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria response to oxygen-glucose deprivation intrinsic apoptotic signaling pathway mitochondrial outer membrane permeabilization granzyme-mediated programmed cell death signaling pathway negative regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitophagy intrinsic apoptotic signaling pathway in response to hypoxia
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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