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Proteintech
Ataxin 2 Monoclonal Antibody (1E8A2), CoraLite® Plus 488
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Product Details
CL488-68316
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
1E8A2
Immunogen
Ataxin 2 fusion protein Ag17402
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Ammonium sulfate precipitation, Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: GSDQRVVNG GVPWPSPCPS PSSRPPSRYQ SGPNSLPPRA ATPTRPPSRP PSRPSRPPSH PSAHGSPAPV STMPKRMSSE GPPRMSPKAQ RHPRNHRVSA GRGSISSGLE FVSHNPPSEA ATPPVARTSP SGGTWSSVVS GVPRLSPKTH RPRSPRQNSI GNTPSGPVLA SPQAGIIPTE AVAMPIPAAS PTPASPASNR AVTPSSEAKD SRLQDQRQNS PAGNKENIKP NETSPSFSKA ENKGISPVVS EHRKQIDDLK KFKNDFRLQP SSTSESMDQL LNKNREGEKS RDLIKDKIEP SAKDSFIENS SSNCTSGSSK PNSPSISPSI LSNTEHKRGP EVTSQGVQTS S
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ataxin-2; FLJ46772; spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2); spinocerebellar ataxia 2 homolog; Spinocerebellar ataxia type 2 protein; Spinocerebellar ataxia type 2 protein homolog; Trinucleotide repeat-containing gene 13 protein
Gene Aliases: 9630045M23Rik; ASL13; ATX2; ATXN2; AW544490; SCA2; TNRC13
UniProt ID: (Human) Q99700, (Mouse) O70305
Entrez Gene ID: (Human) 6311, (Rat) 288663, (Mouse) 20239
negative regulation of receptor internalization
regulation of translation
regulation of cytoplasmic mRNA processing body assembly
RNA metabolic process
cytoplasmic mRNA processing body assembly
stress granule assembly
RNA transport
biological_process
cerebellar Purkinje cell differentiation
negative regulation of multicellular organism growth
neuron projection morphogenesis
homeostasis of number of cells
neuromuscular process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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