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Proteintech
OTUB1 Monoclonal Antibody (2F7F8), CoraLite® Plus 488
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Product Details
CL488-68489
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2F7F8
Immunogen
OTUB1 fusion protein Ag33132
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK SKEDLVSQGF TEFTIEDFHN TFMDLIEQVE KQTSVADLLA SFNDQSTSDY LVVYLRLLTS GYLQRESKFF EHFIEGGRTV KEFCQQEVEP MCKESDHIHI IALAQALSVS IQVEYMDRGE GGTTNPHIFP EGSEPKVYLL YRPGHYDILY K
Target Information
The product of this gene is a member of the OTU superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme OTUB1; deubiquitinating enzyme OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; FLJ20113; FLJ40710; hOTU1; MGC111158; MGC4584; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU domain-containing ubiquitin aldehyde-binding protein 1 {ECO:0000250|UniProtKB:Q7TQI3}; OTU-domain Ubal-binding 1; otub1 {ECO:0000312|EMBL:AAI66771.1}; otubain 1; Otubain-1; otubain-1 {ECO:0000250|UniProtKB:Q7TQI3}; Ubiquitin thioesterase OTUB1; ubiquitin thioesterase OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; ubiquitin-specific protease otubain 1; Ubiquitin-specific-processing protease OTUB1; ubiquitin-specific-processing protease OTUB1 {ECO:0000250|UniProtKB:Q7TQI3}; unnamed protein product
Gene Aliases: AI850305; HSPC263; OTB1; OTU1; OTUB1
UniProt ID: (Human) Q96FW1, (Mouse) Q7TQI3, (Rat) B2RYG6
Entrez Gene ID: (Human) 55611, (Mouse) 107260, (Rat) 293705
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
NEDD8-specific protease activity
ubiquitin protein ligase binding
ubiquitin binding
ubiquitin-protein transferase inhibitor activity
molecular_function
cysteine protease
adaptive immune response
immune system process
DNA repair
proteolysis
cellular response to DNA damage stimulus
protein deubiquitination
cellular response to nutrient levels
TORC1 signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K48-linked deubiquitination
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
negative regulation of double-strand break repair
cellular response to interleukin-1
negative regulation of histone H2A K63-linked ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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