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Proteintech
NFKB2,p100 Recombinant Rabbit Monoclonal Antibody (241126F1), CoraLite® Plus 488
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Product Details
CL488-84022-6
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
241126F1
Immunogen
NFKB2,p100 fusion protein Ag0662
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: GLYPVHLAVR ARSPECLDLL VDSGAEVEAT ERQGGRTALH LATEMEELGL VTHLVTKLRA NVNARTFAGN TPLHLAAGLG YPTLTRLLLK AGADIHAENE EPLCPLPSPP TSDSDSDSEG PEKDTRSSFR GHTPLDLTCS TKVKTLLLNA AQNTMEPPLT PPSPAGPGLS LGDTALQNLE QLLDGPEAQG SWAELAERLG LRSLVDTYRQ TTSPSGSLLR SYELAGGDLA GLLEALSDMG LEEGVRLLRG PETRDKLPST EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH
Target Information
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Lyt10; NF-kB p100; NFKB, p52/p100 subunit; NFKB2 p100 subunit; nuclear factor Kappa-B, subunit 2; Nuclear factor NF-kappa-B p100 subunit; nuclear factor NF-kappa-B p52 subunit; nuclear factor of Kappa light chain gene enhancer in B cells 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); Oncogene Lyt-10; p50-NF-kappa B homolog; transcription factor NFKB2; unnamed protein product
Gene Aliases: CVID10; H2TF1; LYT-10; LYT10; NF-kB2; NFKB2; p100; p49/p100; p52
UniProt ID: (Human) Q00653
Entrez Gene ID: (Human) 4791
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
follicular dendritic cell differentiation
germinal center formation
regulation of transcription, DNA-templated
signal transduction
I-kappaB kinase/NF-kappaB signaling
extracellular matrix organization
response to lipopolysaccharide
response to cytokine
NIK/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
spleen development
intracellular signaling cassette
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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