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Proteintech

PPAR Gamma Monoclonal Antibody (4E12F10), CoraLite® Plus 488

View all (24) PPAR gamma antibodies

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Product Details

CL48860127100UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4E12F10

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Wet ice

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HUMPPARG; Nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor-gamma 5; peroxisome proliferator-activated receptor-gamma splicing; PPAR gamma; PPAR-gamma; PPARy; unnamed protein product

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Gene Aliases: CIMT1; FPLD3; GLM1; NR1C3; PPARG; PPARG1; PPARG2; PPARG5; PPARgamma

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UniProt ID: (Human) P37231

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Entrez Gene ID: (Human) 5468

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding prostaglandin receptor activity protein binding zinc ion binding enzyme binding peptide binding identical protein binding sequence-specific DNA binding metal ion binding retinoid X receptor binding arachidonic acid binding DBD domain binding LBD domain binding WW domain binding alpha-actinin binding R-SMAD binding E-box binding STAT family protein binding DNA-binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter placenta development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter fatty acid metabolic process G-protein coupled receptor signaling pathway response to nutrient regulation of blood pressure hormone-mediated signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux negative regulation of cholesterol storage negative regulation of lipid storage long-chain fatty acid transport negative regulation of angiogenesis cell differentiation monocyte differentiation BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway intracellular receptor signaling pathway epithelial cell differentiation negative regulation of defense response response to nutrient levels positive regulation of cholesterol transport cellular response to insulin stimulus response to lipid peroxisome proliferator activated receptor signaling pathway glucose homeostasis regulation of circadian rhythm mRNA transcription from RNA polymerase II promoter negative regulation of MAPK cascade negative regulation of blood vessel endothelial cell migration innate immune response cell fate commitment positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway cell maturation rhythmic process negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response white fat cell differentiation regulation of transport negative regulation of multicellular organismal process lipid homeostasis negative regulation of interferon-gamma-mediated signaling pathway negative regulation of SMAD protein import into nucleus positive regulation of adiponectin secretion cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia negative regulation of mitochondrial fission positive regulation of lipoprotein transport nuclear receptor-mediated signaling pathway regulation of cellular response to insulin stimulus negative regulation of extracellular matrix assembly negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of cellular response to transforming growth factor beta stimulus positive regulation of adipose tissue development negative regulation of connective tissue replacement involved in inflammatory response wound healing negative regulation of vascular smooth muscle cell proliferation negative regulation of receptor signaling pathway via STAT positive regulation of vascular associated smooth muscle cell apoptotic process negative regulation of vascular endothelial cell proliferation positive regulation of apoptotic signaling pathway
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