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Proteintech
EED Monoclonal Antibody (1D11D4), CoraLite® Plus 488
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Product Details
CL48867756100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1D11D4
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
The EED protein (WAIT-1 or WD protein associated with integrin cytoplasmic tails-1), also called embryonic ectoderm development, is a member of the superfamily of WD-40 repeat proteins and widely conserved polycomb group (PcG) family of proteins. The polycomb group (PcG) is a large and evolutionarily conserved set of genes whose products act in multimeric complexes to modify histones, which are then thought to cause stable and heritable states of transcriptional repression. EED shuttles between the nucleus and the plasma membrane and can interact with the cytoplasmic tail of integrin Beta-7 subunit. EED exerted an antiviral activity at the late stage of HIV-1 replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EED; polycomb group protein; Embryonic ectoderm development protein; Heed; lethal, Chr 7, Rinchik 5; Polycomb protein EED; polycomb-group protein; similar to Mus musculus Eed; unnamed protein product; WAIT-1; WD protein associating with integrin cytoplasmic tails 1
Gene Aliases: COGIS; EED; ENSMUSG00000039373; HEED; l(7)5Rn; l7Rn5; lusk; WAIT1
UniProt ID: (Human) O75530, (Mouse) Q921E6
Entrez Gene ID: (Human) 8726, (Mouse) 13626
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
spinal cord development
heterochromatin assembly
negative regulation of transcription, DNA-templated
oligodendrocyte differentiation
genetic imprinting
facultative heterochromatin formation
cellular response to leukemia inhibitory factor
regulation of adaxial/abaxial pattern formation
regulation of gene expression by genetic imprinting
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
histone methylation
positive regulation of histone H3-K27 methylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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