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Proteintech
CD244 Monoclonal Antibody (2B4.69), CoraLite® Plus 555
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Product Details
CL555-65270
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B4.69
Immunogen
fusion protein
Conjugate
Excitation/Emission Max
554/570 nm
Form
Liquid
Concentration
5 µL/Test
Purification
Affinity chromatography
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; CD244; CD244 molecule, natural killer cell receptor 2B4; cell surface glycoprotein; immunoglobulin superfamily; h2B4; NAIL; Natural killer cell receptor 2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell type I receptor protein 2B4; NKR Nmrk; NKR2B4; Signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4; unnamed protein product
Gene Aliases: 2B4; CD244; NAIL; NKR2B4; Nmrk; SLAMF4
UniProt ID: (Human) Q9BZW8
Entrez Gene ID: (Human) 51744
adaptive immune response
natural killer cell activation involved in immune response
immune system process
immune response
signal transduction
natural killer cell activation
positive regulation of interferon-gamma production
positive regulation of interleukin-8 production
innate immune response
positive regulation of inositol phosphate biosynthetic process
positive regulation of granzyme B production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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