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Proteintech
DDX21 Monoclonal Antibody (1B9C8), CoraLite® 555
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Product Details
CL555-66925
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B9C8
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
555/570 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: GATSVDQRSL INSNVGFVTM ILQCSIEMPN ISYAWKELKE QLGEEIDSKV KGMVFLKGKL GVCFDVPTAS VTEIQEKWHD SRRWQLSVAT EQPELEGPRE GYGGFRGQRE GSRGFRGQRD GNRRFRGQRE GSRGPRGQRS GGGNKSNRSQ NKGQKRSFSK AFGQ
Target Information
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DEAD (Asp-Glu-Ala-Asp) box helicase 21; DEAD box protein 21; DEAD-box helicase 21; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21; Gu protein; Gu-alpha; Nucleolar RNA helicase 2; Nucleolar RNA helicase Gu; Nucleolar RNA helicase II; RH II/Gu; RNA helicase II/Gu alpha; unnamed protein product
Gene Aliases: DDX21; gu-alpha; GUA; GURDB; II/Gu; RH; RH II/Gu; RH-II/GU; RH-II/GuA
UniProt ID: (Human) Q13436
Entrez Gene ID: (Human) 9188
nucleotide binding
nucleic acid binding
RNA binding
RNA helicase activity
double-stranded RNA binding
mRNA binding
helicase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
rRNA binding
snoRNA binding
miRNA binding
identical protein binding
7SK snRNA binding
RNA polymerase inhibitor activity
osteoblast differentiation
immune system process
positive regulation of myeloid dendritic cell cytokine production
chromatin remodeling
rRNA processing
transcription from RNA polymerase II promoter
response to virus
regulation of gene expression
positive regulation of macromolecule biosynthetic process
negative regulation of transcription from RNA polymerase I promoter
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
innate immune response
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
defense response to virus
R-loop processing
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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