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Proteintech

AGT Monoclonal Antibody (1B2F5), CoraLite® 594

View all (21) Angiotensinogen antibodies

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AGT Monoclonal Antibody (1B2F5), CoraLite® 594

Product Details

CL594-68020

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.4 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Pig

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1B2F5

Immunogen

Recombinant protein
3D Epitope / Immunogen

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: PTAVFGTLAS LYLGALDHTA DRLQAILGVP WKDKNCTSRL DAHKVLSALQ AVQGLLVAQG RADSQAQLLL STVVGVFTAP GLHLKQPFVQ GLALYTPVVL PRSLDFTELD VAAEKIDRFM QAVTGWKTGC SLTGASVDST LAFNTYVHFQ GKMKGFSLLA EPQEFWVDNS TSVSVPMLSG MGTFQHWSDI QDNFSVTQVS FTESACLLLI QPHYASDLDK VEGLTFQQNS LNWMKKLSPR TIHLTMPQLV LQGSYDLQDL LAQAELPAIL HTELNLQKLS NDRIRVGEVL NSIFFELEAD EREPTESTQQ LNKPEVLEVT LNRPFLFAVY DQSATALHFL GRVANPLSTA

Target Information

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; fetal-liver predominant transporter 1; pre-angiotensinogen; preangiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8; unnamed protein product

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Gene Aliases: AGT; ANHU; hFLT1; SERPINA8

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UniProt ID: (Human) P01019

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Entrez Gene ID: (Human) 183, (Pig) 100157073

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Function(s)
serine-type endopeptidase inhibitor activity hormone activity protein binding growth factor activity superoxide-generating NADPH oxidase activator activity sodium channel regulator activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding receptor agonist activity
Process(es)
regulation of cell growth positive regulation of cytokine production kidney development blood vessel remodeling regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of blood vessel size by renin-angiotensin renal system process regulation of systemic arterial blood pressure by renin-angiotensin G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway cell-cell signaling regulation of blood pressure positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of macrophage derived foam cell differentiation response to muscle activity involved in regulation of muscle adaptation regulation of vasoconstriction positive regulation of superoxide anion generation low-density lipoprotein particle remodeling regulation of renal sodium excretion nitric oxide-cGMP-mediated signaling pathway angiotensin-activated signaling pathway regulation of cell proliferation vasoconstriction regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAP kinase activity positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation positive regulation of inflammatory response negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of protein kinase B signaling renal sodium ion absorption positive regulation of branching involved in ureteric bud morphogenesis positive regulation of cholesterol metabolic process regulation of blood vessel diameter positive regulation of angiotensin-activated signaling pathway regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly negative regulation of sodium ion transmembrane transport positive regulation of membrane hyperpolarization positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of gap junction assembly regulation of cardiac conduction response to angiotensin positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway
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