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HNRNPD Monoclonal Antibody (2G9E6), CoraLite® 594

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HNRNPD Monoclonal Antibody (2G9E6), CoraLite® 594

Product Details

CL594-68236

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rabbit, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2G9E6

Immunogen

HNRNPD fusion protein Ag3458
3D Epitope / Immunogen

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MSEEQFGGDG AAAAATAAVG GSAGEQEGAM VAATQGAAAA AGSGAGTGGG TASGGTEGGS AESEGAKIDA SKNEEDEGHS NSSPRHSEAA TAQREEWKMF IGGLSWDTTK KDLKDYFSKF GEVVDCTLKL DPITGRSRGF GFVLFKESES VDKVMDQKEH KLNGKVIDPK RAKAMKTKEP VKKIFVGGLS PDTPEEKIRE YFGGFGEVES IELPMDNKTN KRRGFCFITF KEEEPVKKIM EKKYHNVGLS KCEIKVAMSK EQYQQQQQWG SRGGFAGRAR GRGGGPSQNW NQGYSNYWNQ GYGNYGYNSQ GYGGYGGYDY TGYNNYYGYG DYSNQQSGYG KVSRRGGHQN SYKPY

Target Information

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ARE-binding protein AUFI, type A; AU-rich element RNA binding protein 1, 37kDa; AU-rich element RNA-binding factor 1; AU-rich element RNA-binding protein 1; AU-rich RNA-binding factor 1; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; RNA binding protein p45AUF1; transcription factor; unnamed protein product

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Gene Aliases: AUF1; AUF1A; HNRNPD; hnRNPD0; HNRPD; P37

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UniProt ID: (Human) Q14103, (Mouse) Q60668, (Rat) Q9JJ54

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Entrez Gene ID: (Rabbit) 100354204, (Human) 3184, (Pig) 100512244, (Mouse) 11991, (Rat) 79256

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Function(s)
nucleic acid binding DNA binding AT DNA binding chromatin binding RNA binding mRNA binding protein binding mRNA 3'-UTR AU-rich region binding telomeric DNA binding histone deacetylase binding nucleotide binding poly(A) RNA binding
Process(es)
nuclear-transcribed mRNA catabolic process, exonucleolytic nucleocytoplasmic transport regulation of circadian rhythm regulation of mRNA stability positive regulation of translation mRNA stabilization circadian regulation of translation liver development regulation of transcription, DNA-templated RNA processing RNA catabolic process regulation of gene expression positive regulation of macromolecule biosynthetic process positive regulation of gene expression negative regulation of gene expression cerebellum development positive regulation of telomere maintenance via telomerase response to estradiol positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process response to calcium ion response to electrical stimulus 3'-UTR-mediated mRNA destabilization CRD-mediated mRNA stabilization cellular response to amino acid stimulus cellular response to estradiol stimulus cellular response to nitric oxide negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay response to rapamycin positive regulation of telomere capping response to sodium phosphate cellular response to putrescine hepatocyte dedifferentiation positive regulation of cytoplasmic translation transcription, DNA-templated
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